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Related Concept Videos

Sampling Plans01:23

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Sampling is a crucial step in analytical chemistry, allowing researchers to collect representative data from a large population. Common sampling methods include random, judgmental, systematic, stratified, and cluster sampling.
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Base complementarity between the three base pairs of mRNA codon and the tRNA anticodon is not a failsafe mechanism. Inaccuracies can range from a single mismatch to no correct base pairing at all. The free energy difference between the correct and nearly correct base pairs can be as small as 3 kcal/ mol. With complementarity being the only proofreading step, the estimated error frequency would be one wrong amino acid in every 100 amino acids incorporated. However, error frequencies observed in...
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A Novel Method for Improving VMAT Plan Quality and Deliverability.

Natarajan Ramar1,2, Samir Ranjan Meher2

  • 1Philips Health Systems, Philips India Ltd, Bangalore, India.

Asian Pacific Journal of Cancer Prevention : APJCP
|June 28, 2022
PubMed
Summary

A new Volumetric Modulated Arc Therapy (VMAT) method, Augmented Arc (Aug Arc), improves treatment plan quality and delivery. This technique balances single or partial arc efficiency with double arc benefits, optimizing parameters for better outcomes.

Keywords:
Control pointIMRTObjective functionPartial ArcVMAT

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Area of Science:

  • Medical Physics
  • Radiation Oncology
  • Radiotherapy Planning

Background:

  • A novel Volumetric Modulated Arc Therapy (VMAT) technique, termed Augmented Arc (Aug Arc), is introduced.
  • Aug Arc involves augmenting specific portions of a VMAT arc with an additional arc to enhance treatment plan quality.
  • The identification of these Aug Arc portions relies on an objective function-based scoring method, the 'ψ - score'.

Purpose of the Study:

  • To demonstrate the clinical validity and effectiveness of the proposed Augmented Arc (Aug Arc) VMAT method.
  • To evaluate Aug Arc's performance across diverse clinical scenarios, including Lung, Abdomen, Gynecologic (Gyn), and Pancreas cases.
  • To assess the impact of Aug Arc on plan quality and deliverability compared to conventional VMAT techniques.

Main Methods:

  • Four clinical cases (Lung, Abdomen, Gyn, Pancreas) were used to validate the Aug Arc approach.
  • Different plan configurations were generated: Single Arc (S Arc), Double Arc (D Arc), Partial Arc (P Arc), and Augmented Arc (P+Aug Arc or S+Aug Arc).
  • The 'ψ - score' was computed using initial optimization with a full arc and 4-degree gantry spacing to identify optimal Aug Arc portions.

Main Results:

  • The Augmented Arc (Aug Arc) method significantly improved plan quality and deliverability for both central and non-central tumors.
  • Key improvements included reductions in Organs at Risk (OAR) dose, monitor units (MUs), and beam-on time.
  • Low dose volume was reduced without compromising target coverage, indicating enhanced treatment precision.

Conclusions:

  • The proposed Augmented Arc (Aug Arc) approach offers a balanced solution between single/partial arc and full double arc VMAT techniques.
  • Planners can leverage Aug Arc to identify optimal delivery parameters, achieving a 'sweet spot' for superior plan quality.
  • This method enhances radiotherapy planning by optimizing efficiency and therapeutic ratio.