Value of acetylated haemoglobin assay in fetal assessment

Acetylation of fetal haemoglobin, probably a post-translational, intracellular, enzyme-mediated reaction, depends upon an adequate supply of glucose and oxygen to the fetus and the nature of the diabetes (if present) in the mother. These complicating factors limit the general usefulness of acetylated fetal haemoglobin assay in fetal assessment.