Association between Cerebrovascular Risk Factors and Collateral Compensation in Chronic Symptomatic Intracranial
Qi Li1, Benlin Wang1, Yang Sun2
1School of Medicine, Nankai University, Tianjin, China.
Insights
High-density lipoprotein (HDL) is linked to good collateral compensation in intracranial vertebrobasilar stenosis (IVBS). Conversely, higher fasting blood glucose (FBG) and hyperlipidemia correlate with poor collateral compensation in IVBS patients.
Area of Science:
- Neurology
- Vascular Medicine
- Medical Research
Background:
- Collateral compensation is crucial in managing chronic symptomatic intracranial vertebrobasilar stenosis (IVBS).
- Understanding the link between cerebrovascular risk factors and collateral compensation is vital for patient outcomes.
Purpose of the Study:
- To investigate the association between common cerebrovascular risk factors and collateral compensation status in patients with chronic symptomatic IVBS.
- To identify specific risk factors that predict good or poor collateral compensation in IVBS.
Main Methods:
- A single-center, cross-sectional study retrospectively analyzed 238 patients with IVBS.
- Patients were categorized into good collateral compensation (GCC) and poor collateral compensation (PCC) groups based on collateral grade.
- Demographic, laboratory, and clinical data were compared; logistic regression analyzed independent factors of collateral compensation.
Main Results:
- Significant differences were observed in hyperlipidemia, high-density lipoprotein (HDL), and fasting blood glucose (FBG) between GCC and PCC groups.
- Multivariate analysis identified HDL (OR: 1.134), FBG (OR: 0.945), and hyperlipidemia (OR: 0.261) as independent predictors of collateral compensation.
- ROC analysis established cutoff values: HDL 34 mg/dL and FBG 135 mg/dL for differentiating GCC and PCC.
Conclusions:
- Elevated HDL levels are associated with good collateral compensation in IVBS.
- Higher FBG levels and the presence of hyperlipidemia are linked to poor collateral compensation in IVBS patients.
- These findings highlight the importance of managing lipid and glucose levels for optimizing collateral function in IVBS.
Introduction:
The level of collateral compensation plays a pivotal role in chronic symptomatic intracranial vertebrobasilar stenosis (IVBS). This study aimed to evaluate the association between cerebrovascular risk factors and collateral compensation in chronic symptomatic IVBS.
Methods:
This single-center cross-sectional study retrospectively reviewed 238 patients with angiographically demonstrated IVBS and divided them into good collateral compensation (GCC) group (collateral grade: 3-4, n = 110) and poor collateral compensation (PCC) group (collateral grade: 0-2, n = 128). The demographic information, laboratory tests, and clinical data of the two groups were compared and assessed using univariate logistic regression. Multivariate logistic regression was employed to analyze the independent related factors of collateral compensation.
Results:
Hyperlipidemia, high-density lipoprotein (HDL), and fasting blood glucose (FBG) were significantly different between the two groups. Multivariate logistic regression analysis revealed that HDL (odds ratio [OR]: 1.134, 95% confidence interval [CI]: 1.081-1.190), FBG (OR: 0.945, 95% CI: 0.925-0.964), and hyperlipidemia (OR: 0.261, 95% CI: 0.129-0.527) were statistically independent related factors of collateral compensation. The receiver-operating characteristic (ROC) analysis provided cutoff values of 34 mg/dL and 135 mg/dL for HDL and FBG associated with GCC and PCC.
Conclusion:
Higher HDL levels are associated with higher incidence of GCC, whereas higher FBG levels and hyperlipidemia are associated with higher incidence of PCC.
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