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Alcohol consumption and smoking in relation to psoriasis: a Mendelian randomization study
Jiahe Wei1, Jiahao Zhu1, Huiqing Xu1
1Department of Epidemiology and Health Statistics, School of Public Health, Hangzhou Medical College, Hangzhou, China.
The British Journal of Dermatology
|June 28, 2022
Summary
This study provides causal evidence that smoking increases psoriasis risk. Alcohol consumption was not found to be causally linked to psoriasis. Reducing smoking may help lower the burden of psoriasis.
Area of Science:
- Genetics
- Dermatology
- Epidemiology
Background:
- Observational studies suggest associations between alcohol consumption, smoking, and psoriasis risk.
- High-quality evidence for causality is lacking.
- This study investigates the causal links between smoking, alcohol use, and psoriasis.
Approach:
- Utilized genome-wide association study (GWAS) summary data for alcohol consumption and various smoking metrics (initiation, cigarettes per day, cessation, lifetime smoking).
- Employed linkage disequilibrium score regression to calculate genetic correlations.
- Conducted bidirectional Mendelian randomization (MR) analyses using independent genome-wide significant genetic variants to establish causal direction.
Key Points:
- MR analyses revealed a causal effect of smoking initiation (OR 1.46), cigarettes per day (OR 1.38), and lifetime smoking (OR 1.96) on psoriasis risk.
- A suggestive causal effect of smoking cessation on psoriasis was also observed (OR 1.39).
- No statistically significant causal relationship was found between alcohol consumption and psoriasis (P=0.379).
Conclusions:
- This Mendelian randomization study provides robust causal evidence linking smoking to an increased risk of developing psoriasis.
- No causal association was identified between alcohol consumption and psoriasis.
- Findings suggest that smoking cessation could be a beneficial strategy for reducing the public health burden of psoriasis.
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