Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Protein Networks02:26

Protein Networks

4.1K
An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
4.1K
Stability of structures01:14

Stability of structures

242
In mechanical engineering, the stability of systems under various forces is critical for designing durable and efficient structures. One fundamental way to explore these concepts is by analyzing systems like two rods connected at a pivot point, O, with a torsional spring of spring constant k at the pivot point. This system is similar in appearance to a scissor jack used to change tires on a car. In this case, the arms of the linkage (equivalent to the rods in this system) are entirely vertical,...
242
Structural Protein Function01:56

Structural Protein Function

2.8K
2.8K
Internal Loadings in Structural Members: Problem Solving01:28

Internal Loadings in Structural Members: Problem Solving

1.4K
When designing or analyzing a structural member, it is important to consider the internal loadings developed within the member. These internal loadings include normal force, shear force, and bending moment. Engineers can ensure that the structural member can support the applied external forces by calculating these internal loadings.
To illustrate this, let's consider a beam OC of 5 kN, inclined at an angle of 53.13° with the horizontal and supported at both ends. Determine the internal...
1.4K
Design Consideration01:22

Design Consideration

316
Designing a structure involves a series of considerations, primarily the material's ultimate strength, calculated through tests that measure changes under increased force until the material reaches its breaking point or limit. The ultimate load, where the material breaks, is divided by its original cross-sectional area, resulting in the ultimate normal stress or strength. The ultimate shearing stress is another significant factor taken into account.
The factor of safety is another key...
316
Protein-protein Interfaces02:04

Protein-protein Interfaces

13.2K
Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a...
13.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Mannan-Binding Lectin Inhibits Candida Albicans-Induced DC Maturation and Cytokine Secretion].

Zhongguo shi yan xue ye xue za zhi·2015
Same author

Epsilon-caprolactone modified polyethylenimine for highly efficient antigen delivery and chemical exchange saturation transfer functional MR imaging.

Biomaterials·2015
Same author

Nitrogen-Doped Carbon Nanotube Aerogels for High-Performance ORR Catalysts.

Small (Weinheim an der Bergstrasse, Germany)·2015
Same author

TIPE2 protein prevents injury-induced restenosis in mice.

Biochimica et biophysica acta·2015
Same author

Uncovering the thermodynamics of monomer binding for RNA replication.

Journal of the American Chemical Society·2015
Same author

[Effect of estrogen-like effective part of Selaginella tarmariscina on bone metabolism in ovariectomized rats].

Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials·2015

Related Experiment Video

Updated: Sep 6, 2025

Optimization of Synthetic Proteins: Identification of Interpositional Dependencies Indicating Structurally and/or Functionally Linked Residues
07:08

Optimization of Synthetic Proteins: Identification of Interpositional Dependencies Indicating Structurally and/or Functionally Linked Residues

Published on: July 14, 2015

7.4K

Improve the product structural robustness based on network motifs in product development.

Yongbo Ni1, Yingxia Ou1, Yupeng Li2

  • 1Department of Industrial Engineering, China University of Mining and Technology, Xuzhou, 221116, Jiangsu, China.

Scientific Reports
|June 28, 2022
PubMed
Summary

Product structural networks reveal that specific motifs enhance robustness, while anti-motifs decrease it. This research offers universal strategies for optimizing product structure and improving safety and stability.

More Related Videos

Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules
10:58

Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules

Published on: July 25, 2013

17.1K
Application of I TASSER, trRosetta, UCSF Chimera, HADDOCK server, and HEX loria for De Novo and In Silico Design of Proteins
05:08

Application of I TASSER, trRosetta, UCSF Chimera, HADDOCK server, and HEX loria for De Novo and In Silico Design of Proteins

Published on: July 8, 2025

324

Related Experiment Videos

Last Updated: Sep 6, 2025

Optimization of Synthetic Proteins: Identification of Interpositional Dependencies Indicating Structurally and/or Functionally Linked Residues
07:08

Optimization of Synthetic Proteins: Identification of Interpositional Dependencies Indicating Structurally and/or Functionally Linked Residues

Published on: July 14, 2015

7.4K
Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules
10:58

Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules

Published on: July 25, 2013

17.1K
Application of I TASSER, trRosetta, UCSF Chimera, HADDOCK server, and HEX loria for De Novo and In Silico Design of Proteins
05:08

Application of I TASSER, trRosetta, UCSF Chimera, HADDOCK server, and HEX loria for De Novo and In Silico Design of Proteins

Published on: July 8, 2025

324

Area of Science:

  • Engineering
  • Network Science
  • Product Design

Background:

  • Product stability and safety are compromised by vulnerable structures and component failures.
  • Current methods for enhancing structural robustness lack universal and explicit design strategies.
  • Analyzing product structures as networks, focusing on fundamental meta-structures called motifs, offers an efficient approach.

Purpose of the Study:

  • To explore strategies for improving product structural robustness by analyzing the relationships between typical motifs and robustness.
  • To develop universal and explicit structure optimization strategies for product development.

Main Methods:

  • Constructing product structural networks from generational structural data.
  • Identifying typical (anti-) motifs using an enumeration algorithm and measuring robustness via the largest connected cluster.
  • Utilizing principal component regression to determine relationships between motif frequency and product structural robustness.

Main Results:

  • A case study on smartphones demonstrated that anti-motifs negatively impact product structural robustness.
  • Motifs incorporating loop structures were found to positively correlate with product structural robustness.
  • Established clear relationships between the prevalence of specific motifs and overall product robustness.

Conclusions:

  • Anti-motifs are detrimental to product structural robustness.
  • Motifs with loop structures are beneficial for enhancing product structural robustness.
  • Developed actionable strategies for improving product structural robustness in product development based on motif analysis.