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Safety and Adverse Events Related to COVID-19 mRNA Vaccines; a Systematic Review

SeyedAhmad SeyedAlinaghi1, Amirali Karimi2, Zahra Pashaei1

  • 1Iranian Research Center for HIV/AIDS, Iranian Institute for Reduction of High Risk Behaviors, Tehran University of Medical Sciences, Tehran, Iran.

Archives of Academic Emergency Medicine
|June 29, 2022
PubMed
Abstract

Insights

Adverse events from mRNA COVID-19 vaccines are important for vaccine confidence. This review found cardiac complications were common severe events, but benefits of mRNA vaccines outweigh risks.

Area of Science:

  • Immunology
  • Public Health
  • Pharmacovigilance

Background:

  • Vaccine hesitancy is a significant public health challenge.
  • Understanding vaccine-related adverse events is crucial for promoting vaccine uptake.
  • mRNA vaccines have been pivotal in controlling the COVID-19 pandemic.

Purpose of the Study:

  • To systematically review adverse events associated with mRNA COVID-19 vaccines.
  • To identify common and severe adverse events reported in the literature.
  • To assess the safety profile of mRNA COVID-19 vaccines.

Main Methods:

  • Systematic literature search conducted across Scopus, PubMed, Cochrane, and Web of Science.
  • Inclusion of original studies detailing side effects of mRNA COVID-19 vaccines.
  • Two-phase screening process (title/abstract and full-text) for study selection.

Main Results:

  • Cardiac complications were the most frequently reported severe adverse events.
  • Systemic reactions were more common after the second vaccine dose.
  • While myopericarditis showed a higher prevalence, no significant association was found between mRNA vaccines and cardiac events overall.

Conclusions:

  • The benefits of mRNA COVID-19 vaccines significantly outweigh their adverse events.
  • Continued monitoring of vaccine safety is essential for public trust.
  • mRNA vaccines remain a critical tool in pandemic management and mortality reduction.
Keywords:
2019-nCoV Vaccine mRNA-1273Adverse effects; COVID-19 vaccinesBNT162 VaccinemRNA vaccines

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