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 The nursing management of a patient with peripheral artery disease (PAD) begins with a thorough assessment of the patient’s health history and clinical manifestations.AssessmentHealth History: Evaluate the patient’s history of hypertension, hyperlipidemia, family history of cardiovascular issues, and lifestyle factors such as dietary patterns, smoking, and physical activity.Physical Examination:Assess the affected extremity for decreased or absent peripheral pulses,...
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Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
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Related Experiment Video

Updated: Sep 6, 2025

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Peripheral Ulcerative Keratitis: A Review.

Kiana Hassanpour1, Reem H ElSheikh2, Amir Arabi1

  • 1Ophthalmic Research Center, Research Institute for Ophthalmology and Vision Science, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Journal of Ophthalmic & Vision Research
|June 29, 2022
PubMed
Summary
This summary is machine-generated.

Peripheral ulcerative keratitis (PUK) is a severe eye condition involving corneal thinning. Early diagnosis and treatment of underlying causes, including autoimmune diseases, are crucial for managing PUK and preventing vision loss.

Keywords:
Immunomodulatory TherapyAutoimmune DiseaseUlcerative Keratitis

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Area of Science:

  • Ophthalmology
  • Immunology

Background:

  • Peripheral ulcerative keratitis (PUK) is a rare, serious ocular condition with significant ophthalmological and systemic implications.
  • It involves progressive peripheral corneal thinning and epithelial defects, often linked to inflammatory conditions or presenting as Mooren ulcer.
  • Associated conditions include autoimmune diseases, infections, dermatologic disorders, and post-ocular surgery complications.

Purpose of the Study:

  • To summarize the clinical presentation, pathogenesis, diagnostic approaches, and management strategies for peripheral ulcerative keratitis.
  • To highlight the role of immune responses in PUK pathogenesis and the efficacy of various treatment modalities.

Main Methods:

  • Literature review and synthesis of current knowledge on PUK.
  • Analysis of clinical features, diagnostic criteria, and treatment outcomes.

Main Results:

  • PUK pathogenesis involves cell-mediated and auto-antibody-mediated immune responses, leading to corneal tissue destruction via matrix metalloproteinases.
  • Clinical presentation includes painful vision loss, peripheral corneal ulcer, and associated ocular inflammation (scleritis, iritis).
  • Diagnosis requires identifying the underlying etiology and differentiating from similar conditions like marginal keratitis.

Conclusions:

  • Effective management of PUK necessitates addressing the underlying cause, employing topical lubrication, antimicrobials, or anti-inflammatories as indicated.
  • Biologic immunomodulatory therapies show promise for autoimmune-related PUK.
  • Surgical intervention is reserved for severe cases with significant thinning or perforation.