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Updated: Sep 6, 2025

Dynamic Adhesion Assay for the Functional Analysis of Anti-adhesion Therapies in Inflammatory Bowel Disease
Published on: September 20, 2018
Vedolizumab-Induced Acute Interstitial Nephritis in Ulcerative Colitis
Deloshaan Subhaharan1, Pradeep K Ramaswamy1, Sewwandi Francisco2
1Department of Digestive Diseases, Gold Coast University Hospital, Gold Coast, Australia.
Abstract:
Vedolizumab is used in the treatment of inflammatory bowel disease and is generally well tolerated. We report a 20-year-old man who presented with right flank pain on a background of ulcerative colitis. He was on vedolizumab with his last dose 1 week before the onset of symptoms. Kidney function tests revealed a serum creatinine of 171 μmoL/L and a C-reactive protein of 74 mg/L. Kidney biopsy demonstrated focal acute interstitial nephritis. He was prescribed oral prednisolone and achieved complete recovery of renal function within 3 weeks. At the follow-up after 4 months, his renal function remains normal.
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