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Related Concept Videos

Esophageal Strictures-I: Introduction01:30

Esophageal Strictures-I: Introduction

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Esophageal strictures involve abnormal narrowing or tightening of the esophagus. They vary in length and severity, ranging from mild constriction to complete obstruction, and are classified as benign (noncancerous) or malignant (cancerous).
Etiology
The primary cause of esophageal strictures is long-standing gastroesophageal reflux disease (GERD), accounting for about 70 to 80% of adult cases. Chronic acid reflux can lead to injury and scarring of the esophageal lining, culminating in...
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Barrett Esophagus-II: Clinical Manifestations and Management01:21

Barrett Esophagus-II: Clinical Manifestations and Management

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Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
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Esophagus01:24

Esophagus

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The esophagus, a muscular conduit linking the pharynx and stomach, measures roughly 10 inches (25.4 cm) and sits behind the trachea. It remains collapsed when not swallowing. The esophagus follows a predominantly straight path through the thoracic mediastinum and enters the abdominal cavity through a diaphragmatic opening known as the esophageal hiatus.
The movement of edibles from the pharynx into the esophagus is facilitated by the upper esophageal sphincter, which is formed primarily by the...
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Barrett Esophagus-I: Introduction01:21

Barrett Esophagus-I: Introduction

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Barrett's esophagus is a medical condition where the esophageal mucosa is significantly damaged by stomach acid or other digestive fluids, often due to long-term exposure associated with gastroesophageal reflux disease (GERD). In GERD, a weakened or abnormally relaxed lower esophageal sphincter allows stomach acid to flow persistently into the esophagus.
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more...
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Esophageal Strictures-II: Clinical Features and Management01:26

Esophageal Strictures-II: Clinical Features and Management

155
Patients with esophageal strictures often experience a range of symptoms. Initially, they may have difficulty swallowing solid foods, which can progress to include liquids. Additional symptoms may involve chest pain or discomfort, regurgitating food and fluids, heartburn, unintentional weight loss, coughing or choking during meals, and hoarseness.
Healthcare providers should gather a comprehensive medical history and conduct a physical examination for diagnosis. If esophageal stricture is...
155
Sexually Transmitted Infections01:26

Sexually Transmitted Infections

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Sexually transmitted infections (STIs) are diseases transmitted primarily through unsafe sexual interactions. Bacteria, viruses, or parasites cause them and can result in severe health complications if untreated.ChlamydiaThe bacterium Chlamydia trachomatis is responsible for the disease Chlamydia, the most common STI in the United States. This peculiar pathogen requires human cells to reproduce, residing intracellularly. The initial infection often goes unnoticed because it typically does not...
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Related Experiment Video

Updated: Sep 6, 2025

ADSC-sheet Transplantation to Prevent Stricture after Extended Esophageal Endoscopic Submucosal Dissection
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Syphilis in the Esophagus.

Ronan Allencherril1, Paul Nicholls2, Shilpa Jain3

  • 1Department of Internal Medicine, Baylor College of Medicine, Houston, TX.

ACG Case Reports Journal
|June 29, 2022
PubMed
Summary
This summary is machine-generated.

A rare case of esophageal syphilis, presenting with painful swallowing and oral lesions, was diagnosed and successfully treated with penicillin. This highlights the need to consider syphilis in diverse clinical presentations, even in the absence of HIV.

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Author Spotlight: Investigating the Pathophysiology of Eosinophilic Esophagitis
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Author Spotlight: Investigating the Pathophysiology of Eosinophilic Esophagitis
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Area of Science:

  • Infectious Diseases
  • Gastroenterology
  • Dermatology

Background:

  • Syphilis is a complex sexually transmitted infection with diverse clinical manifestations.
  • Esophageal involvement in syphilis is exceptionally rare, especially in the contemporary era and in individuals without HIV.
  • Historical documentation suggests esophageal syphilis was more common in earlier periods.

Observation:

  • A patient presented with persistent odynophagia (painful swallowing) and recurrent oral lesions.
  • Endoscopic examination revealed a significant esophageal ulcer.
  • Biopsy of the ulcer confirmed the presence of syphilis.

Findings:

  • The patient was diagnosed with esophageal syphilis based on clinical, endoscopic, and histopathological findings.
  • Treatment with intramuscular penicillin led to rapid resolution of symptoms.
  • This case underscores the varied presentations of syphilis.

Implications:

  • Clinicians should maintain a broad differential diagnosis for odynophagia and unexplained oral or mucosal lesions.
  • Syphilis should be considered even in atypical presentations and in patients without known risk factors like HIV.
  • Early diagnosis and treatment are crucial for managing syphilis and preventing complications.