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Updated: Sep 6, 2025

The Synthesis, Characterization and Reactivity of a Series of Ruthenium N-triphosPh Complexes
Published on: April 10, 2015
Ruthenium-Catalyzed Enantioselective Hydrogenation of 9-Phenanthrols
Shu-Xin Zhang1,2, Cong Xu1, Niannian Yi1
1Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences (CAS), Beijing, 100190, P. R. China.
Abstract:
The enantioselective hydrogenation of arenols to corresponding chiral cyclic alcohols remains a challenge because of their aromaticity and the difficulty in controlling the regio-, chemo-, and stereoselectivity. In this work, the first highly efficient ruthenium-catalyzed enantioselective hydrogenation of 9-phenanthrols has been successfully realized under mild conditions via trapping the unstable keto tautomers. The method provides a facile access to a range of chiral 9,10-dihydrophenanthren-9-ols with up to 98 % yield and >99 % ee. The hydrogenation pathway includes base-promoted tautomerization of 9-phenanthrols and Ru-catalyzed asymmetric hydrogenation of the in situ generated unstable keto tautomers.
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