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Updated: Sep 6, 2025

Histological Quantification to Determine Lung Fungal Burden in Experimental Aspergillosis
Published on: March 9, 2018
Challenges in the Treatment of Invasive Aspergillosis in Immunocompromised Children
Alice J Hsu1, Pranita D Tamma2, Brian T Fisher3
1The Johns Hopkins Hospital, Department of Pharmacy, Baltimore, Maryland, USA.
Abstract:
Invasive aspergillosis (IA) is associated with significant morbidity and mortality. Voriconazole remains the drug of choice for the treatment of IA in children; however, the complex kinetics of voriconazole in children make dosing challenging and therapeutic drug monitoring (TDM) essential for treatment success. The overarching goal of this review is to discuss the role of voriconazole, posaconazole, isavuconazole, liposomal amphotericin B, echinocandins, and combination antifungal therapy for the treatment of IA in children. We also provide a detailed discussion of antifungal TDM in children.
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