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Assessment of the Relationship Between the Adropin Levels and the Coronary Collateral Circulation in Patients wıth
Hasan Akkaya1, Ertuğrul Emre Güntürk1, Fulya Akkaya2
1Departamento de Cardiologia, Universidade Niğde Ömer Halisdemir, Hospital Acadêmico e de Pesquisa da Faculdade de Medicina, Niğde - Turquia.
Insights
Higher adropin levels are associated with better coronary collateral circulation (CCC) in patients with chronic coronary syndrome (CCS). This peptide hormone may predict the development of good CCC, offering potential therapeutic insights.
Area of Science:
- Cardiology
- Endocrinology
- Vascular Biology
Background:
- Coronary collateral circulation (CCC) is vital for myocardial protection during ischemia.
- Nitric oxide (NO) and vascular endothelial growth factor (VEGF) are key factors in CCC development.
- Adropin, an energy homeostasis peptide, positively influences endothelial function via NO and VEGF.
Purpose of the Study:
- To investigate the association between adropin levels and the presence of CCC in patients with chronic coronary syndrome (CCS).
Main Methods:
- 102 CCS patients with at least one occluded coronary artery were categorized into poor (Rentrop 0-1) and good (Rentrop 2-3) CCC groups.
- Adropin levels were measured and statistically analyzed in relation to CCC severity and clinical parameters.
Main Results:
- Patients with good CCC exhibited significantly higher adropin levels compared to those with poor CCC (268.25±28.94 pg/mL vs 210.83±17.76 pg/mL, p<0.001).
- Adropin levels positively correlated with Rentrop scores (r:0.76, p<0.001) and negatively with age and Gensini scores.
- Adropin level is a strong independent predictor of good CCC development (OR:1.12, p<0.001).
Conclusions:
- Adropin levels are significantly associated with the presence and severity of coronary collateral circulation in patients with chronic coronary syndrome.
- Adropin may serve as a potential biomarker for predicting good CCC development in CCS patients.
Background:
Coronary collateral circulation (CCC) provides an alternative blood flow to myocardial tissue exposed to ischemia and helps to preserve myocardial functions. Endothelial-derived nitric-oxide (NO) production and vascular endothelial growth factor (VEGF) have been suggested as the most important factors in the development of CCC. Adropin is a peptide hormone responsible for energy hemostasis, and is known for its positive effects on the endothelium through NO and VEGF.
Objective:
The aim of this study is to investigate the association between adropin and the presence of CCC in patients with chronic coronary syndrome (CCS).
Methods:
A total of 102 patients with CCS, who had complete occlusion of at least one major epicardial coronary artery, were included in the study and were divided into two groups: the group of patients (n:50) with poor CCC (Rentrop 0-1) and the group of patients (n:52) with good CCC (Rentrop 2-3). The level of significance adopted in the statistical analysis was 5%.
Results:
Mean adropine levels were found as 210.83±17.76 pg/mL and 268.25±28.94 pg/mL in the poor and good CCC groups, respectively (p<0.001). Adropin levels proved to be positively correlated with neutrophil-to-lymphocyte ratios (r:0.17, p:0.04) and the rentrop scores (r:0.76, p<0.001), and negatively correlated with age (r:-0.23, p:0.01) and Gensini scores (r:-0.19, p:0.02). Adropin level is a strong independent predictor of good CCC development (OR:1.12, 95% CI:(1.06-1.18), p<0.001).
Conclusion:
This study suggests that adropin levels may be a possible factor associated with the presence of CCC in CCS patients.
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