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Updated: Sep 6, 2025

Design, Synthesis, and Photochemical Properties of Clickable Caged Compounds
Published on: October 15, 2019
Design and Synthesis of a Doubly Functionalized Core Structure of a Glycosylphosphatidylinositol Anchor Containing
Venkanna Babu Mullapudi1, Kendall C Craig1, Zhongwu Guo1
1Department of Chemistry, University of Florida, 214 Leigh Hall, Gainesville, Florida 32611, United States.
Abstract:
A bifunctional derivative of the core structure of glycosylphosphatidylinositol (GPI) anchors having a clickable alkynyl group and a photoreactive diazirine group attached to the GPI glucosamine and lipid moieties, respectively, was synthesized from myo-inositol, d-glucosamine, and (R)-1,2-O-acetonized glycerol. The target molecule should be useful for the investigation of GPI-interacting components in the cell membrane that play a key role in the signal transduction and other biological functions of GPI-anchored proteins.
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