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Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...

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Updated: Sep 6, 2025

High-throughput Screening for Chemical Modulators of Post-transcriptionally Regulated Genes

High-throughput Screening for Chemical Modulators of Post-transcriptionally Regulated Genes

Published on: March 3, 2015

High-Throughput Platform for Novel Reaction Discovery.

Xiao Lu¹, Zhiji Luo¹, Ruili Huang²

¹Therapeutic Development Branch, National Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH), Rockville, MD-20850, USA.

Chemistry (Weinheim an Der Bergstrasse, Germany)

|June 29, 2022

Summary

This summary is machine-generated.

A new purification method allows rapid, high-throughput isolation of chemical products. This technique enables efficient reaction discovery, identifying novel chemical transformations in large-scale synthesis.

Keywords:

UV/Vis spectroscopy high-throughput screening synthetic methods

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Last Updated: Sep 6, 2025

High-throughput Screening for Chemical Modulators of Post-transcriptionally Regulated Genes

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Published on: March 3, 2015

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Published on: February 12, 2021

Optimization of the Ugi Reaction Using Parallel Synthesis and Automated Liquid Handling

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Published on: November 11, 2008

Area of Science:

Organic Chemistry
Chemical Synthesis
Reaction Discovery

Background:

High-throughput synthesis requires efficient detection of new chemical bonds.
Conventional product isolation methods are slow and labor-intensive, limiting scalability.
Developing rapid and scalable purification techniques is crucial for advancing chemical synthesis.

Purpose of the Study:

To develop a miniaturizable purification method for rapid, high-throughput product isolation.
To establish a high-throughput reaction discovery platform based on the novel purification technique.
To demonstrate the platform's utility in identifying new chemical transformations.

Main Methods:

Quaternary ammonium tagging of reaction products.
Miniaturizable purification using inexpensive laboratory equipment.
High-throughput screening of chemical reactions.

Main Results:

Successful rapid, high-throughput isolation of quaternary ammonium-tagged products with high purity.
Establishment of a functional high-throughput reaction discovery platform.
Identification of one previously unreported chemical transformation after screening 1536 reactions.

Conclusions:

The developed purification method is efficient, scalable, and cost-effective for high-throughput synthesis.
The novel platform significantly accelerates reaction discovery and the identification of new chemical transformations.
This approach overcomes limitations of conventional methods in detecting new chemical bonds.