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Related Concept Videos

Diseases of the Liver and Gallbladder01:26

Diseases of the Liver and Gallbladder

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Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
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Rous Sarcoma Virus (RSV) and Cancer01:03

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Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
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Hepatic Portal System01:21

Hepatic Portal System

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The hepatic portal system, a critical part of our circulatory framework, transports nutrient-laden, deoxygenated blood from the gastrointestinal tract and spleen to the liver. This ingenious system plays an indispensable role in maintaining our body's metabolic equilibrium.
At its core, the hepatic portal vein is the result of a confluence of the superior and inferior mesenteric veins along with the splenic vein. Each of these veins has a unique role. The superior mesenteric vein is...
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Related Experiment Video

Updated: Sep 6, 2025

Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2
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SARS-CoV-2 infection and liver involvement.

Mingjia Luo1, Maria Pilar Ballester2,3, Ugo Soffientini4,5

  • 1Division of Medicine, University College London, London, UK.

Hepatology International
|June 29, 2022
PubMed
Summary

The COVID-19 pandemic significantly impacts patients with liver disease, increasing risks. Understanding SARS-CoV-2

Keywords:
Alcohol-related liver diseaseAutoimmune liver diseaseCOVID-19Chronic liver diseaseCirrhosisHepatitis B virus infectionLiver injuryNon-alcoholic fatty liver diseaseSARS-CoV-2Vaccination

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Area of Science:

  • Hepatology and Virology
  • Infectious Diseases
  • Public Health

Background:

  • The COVID-19 pandemic presents a major global health crisis.
  • Patients with pre-existing liver conditions face heightened morbidity and mortality.
  • Elevated liver enzymes are linked to severe COVID-19 outcomes, even without prior liver disease.

Purpose of the Study:

  • To review the mechanisms of SARS-CoV-2-induced liver injury.
  • To examine the effects of COVID-19 on various liver diseases and patient groups.
  • To discuss COVID-19 vaccination strategies for individuals with liver conditions.

Main Methods:

  • Literature review and synthesis of existing research.
  • Analysis of clinical data and epidemiological studies.
  • Discussion of emerging scientific evidence and public health implications.

Main Results:

  • SARS-CoV-2 infection can cause direct liver injury through viral mechanisms.
  • COVID-19 exacerbates outcomes for patients with cirrhosis, NAFLD, viral hepatitis, and other liver conditions.
  • Vaccination data in liver disease populations is emerging and crucial for policy.

Conclusions:

  • Elucidating SARS-CoV-2's impact on the liver is critical for patient management.
  • Targeted strategies are needed to mitigate COVID-19's effects on vulnerable liver disease populations.
  • Evidence-based vaccination guidelines are essential for protecting individuals with liver disease.