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Updated: Sep 6, 2025

Microfluidic Model to Mimic Initial Event of Neovascularization
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An Innovative Simulation Model for Microvascular Training.

Isabel Zucal1, Anna-Lena Feder1, Thura Kyaw1

  • 1From the Institute for Molecular and Cellular Anatomy and Centre of Plastic, Aesthetic, Hand, and Reconstructive Surgery, University of Regensburg; Sarcoma and Musculoskeletal Oncoplastic Division, Department of Orthopaedic Surgery, University of Medicine, Mandalay; and Faculty of Applied Healthcare Science, Deggendorf Institute of Technology.

Plastic and Reconstructive Surgery
|June 29, 2022
PubMed
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This study introduces a novel rat cadaver model with artificial circulation for microsurgical training. This animal-sparing approach enhances surgical skill development by simulating real intraoperative conditions.

Area of Science:

  • Surgical Training and Education
  • Medical Device Development
  • Preclinical Research Models

Background:

  • Microsurgical training is critical for clinical practice.
  • Current models like synthetic and cadaveric options lack circulation, limiting realism.
  • Recreating intraoperative circulatory conditions is a significant challenge in surgical education.

Purpose of the Study:

  • To develop an innovative rat cadaver model with a reestablished circulatory system.
  • To overcome the limitations of traditional microsurgical training models.
  • To provide a realistic, ethical alternative for practicing microsurgical techniques.

Main Methods:

  • An extracorporeal perfusion device was connected to rat cadavers to restore circulation.
  • Perfusion fluid contained patent blue for visualization and heparin to prevent thrombosis.

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  • Indocyanine green fluorescent imaging was used to assess vessel patency and perfusion.

    • Main Results:

    • The novel model successfully reestablished a circulatory system in rat cadavers.
    • Indocyanine green imaging confirmed appropriate vessel patency and extremity perfusion.
    • The technique allowed for effective visualization of microsurgical anastomosis.

    Conclusions:

    • This animal-sparing rat cadaver model with circulation offers a viable solution for ethical surgical training.
    • It enhances microsurgical skill acquisition by simulating critical intraoperative circulatory dynamics.
    • The model holds potential for future research in advanced microsurgical procedures and organ perfusion.