Prior aerobic exercise mitigates the decrease in serum osteoglycin and lipocalin-2 following high-glucose...

Area of Science:

• Endocrinology and Metabolism
• Exercise Physiology
• Nutritional Science

Background:

• Osteoglycin (OGN) and lipocalin-2 (LCN2) are bone-secreted hormones implicated in rodent glucose homeostasis.
• The human endocrine roles of OGN and LCN2 in metabolic regulation remain unclear and contradictory.

Purpose of the Study:

• To investigate the effects of acute aerobic exercise and subsequent meal ingestion on circulating OGN and LCN2 levels in healthy males.
• To elucidate the dynamic interplay between exercise, nutrient intake, and these potential metabolic hormones.

Main Methods:

• Eight healthy males participated in a randomized crossover study.
• Participants underwent a rest-control condition or aerobic cycling exercise (1 hour at 70%-75% V̇o_2peak).
• A high-glucose mixed-nutrient meal was ingested at rest or 3 and 24 hours post-exercise, with blood samples collected for hormone analysis.

Main Results:

• Acute aerobic exercise significantly increased serum LCN2 levels immediately post-exercise and up to 3 hours, while OGN levels remained unchanged.
• High-glucose meal ingestion decreased both OGN and LCN2 levels postprandially.
• Prior exercise elevated postprandial OGN and LCN2 levels when meals were consumed 3 and 24 hours after exercise compared to the control condition.

Conclusions:

• Acute exercise increases circulating LCN2 and influences OGN and LCN2 responses to a mixed-nutrient meal in humans.
• These findings suggest OGN and LCN2 are dynamically associated with energy homeostasis in humans, warranting further investigation into their endocrine roles.