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Related Experiment Video

Updated: Sep 6, 2025

Structured Motor Rehabilitation After Selective Nerve Transfers
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Structured Motor Rehabilitation After Selective Nerve Transfers

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Functional Muscle Transfer after Oncologic Extremity Resection.

Abbas M Hassan1, Eliora A Tesfaye1,2, Abhi Rashiwala1,2

  • 1Department of Plastic and Reconstructive Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas.

Journal of Reconstructive Microsurgery
|June 29, 2022
PubMed
Summary
This summary is machine-generated.

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Plastic and reconstructive surgery·2026

Functional muscle transfer (FMT) improves extremity function after cancer surgery. Careful planning and consideration of risk factors like chemotherapy and BMI are crucial for successful outcomes in oncologic reconstruction.

Area of Science:

  • Orthopedic Oncology
  • Reconstructive Surgery
  • Microsurgery

Background:

  • Functional muscle transfer (FMT) is vital for wound closure and muscle function restoration in oncologic extremity defects.
  • This study details institutional experience and synthesizes literature on FMT following oncological resection.

Approach:

  • A retrospective review of 13 patients undergoing FMT from 2005-2021 at a single institution.
  • A systematic review and meta-analysis of 7 studies (70 patients) and 28 studies (103 patients) respectively, adhering to PRISMA guidelines.

Key Points:

  • Meta-analysis showed a mean Medical Research Council (MRC) score of 3.78, indicating functional improvement.
  • Adjuvant chemotherapy correlated with lower MRC scores (3.00 vs. 3.90).
  • Free FMT using latissimus dorsi was most common (74% and 55%). Complication risks increased with neoadjuvant chemotherapy, radiotherapy, pedicled FMTs, and femoral nerve recipient site.

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  • High BMI was linked to prolonged neuromuscular recovery (R=0.87, p=0.002).

    • Conclusions:

    • FMT can enhance extremity function post-oncologic resection.
    • Preoperative risk factor assessment and meticulous planning are essential for optimal FMT results.