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Related Concept Videos

Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

65
Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
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Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

77
Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
77
Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

81
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
81
Acute Kidney Injury III: Clinical Manifestations01:29

Acute Kidney Injury III: Clinical Manifestations

83
Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...
83
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

56
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
56
Factors Affecting Renal Clearance: Renal Impairment01:17

Factors Affecting Renal Clearance: Renal Impairment

154
Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
154

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Related Experiment Video

Updated: Sep 6, 2025

Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

16.4K

Ageing meets kidney disease.

Alberto Ortiz1,2,3, Francesco Mattace-Raso4, María José Soler5

  • 1Department of Nephrology and Hypertension, IIS-Fundacion Jimenez Diaz UAM, Madrid, Spain.

Age and Ageing
|June 29, 2022
PubMed
Summary
This summary is machine-generated.

Chronic kidney disease (CKD) affects kidney structure and function, impacting health and increasing mortality risk, especially in older adults. This review covers CKD

Keywords:
ageingchronic kidney diseasecognitive declinehaemodialysissarcopaeniatransplantation

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Area of Science:

  • Nephrology
  • Gerontology
  • Public Health

Background:

  • Chronic kidney disease (CKD) is characterized by kidney structure or function abnormalities lasting over three months.
  • Diagnostic criteria include albumin:creatinine ratio ≥30 mg/g or estimated glomerular filtration rate (eGFR) <60 mL/min/1.73 m2.
  • CKD prevalence increases with age, posing significant health implications and mortality risks.

Purpose of the Study:

  • To provide an overview of key topics concerning kidney disease and ageing.
  • To highlight the association between CKD, accelerated ageing, and mortality.
  • To discuss various aspects of CKD including morbidity, mortality, and management.

Main Methods:

  • Review of selected studies published in Age&Ageing, NDT, and CKJ.
  • Analysis of data concerning CKD prevalence, risk factors, and outcomes.
  • Synthesis of information on cognitive decline, sarcopaenia, wasting, and cardiovascular/non-cardiovascular morbidity and mortality in CKD patients.

Main Results:

  • CKD is linked to increased all-cause and cardiovascular death, particularly in individuals over 75 years.
  • Premature death is a more frequent outcome than progression to kidney failure.
  • CKD is projected to become the second leading cause of death globally by the end of the century.

Conclusions:

  • CKD represents a growing global health challenge, significantly impacted by population ageing.
  • The review underscores the multifaceted impact of CKD on health, encompassing cognitive function, physical frailty, and mortality.
  • Further research and management strategies are crucial for addressing CKD burden in ageing populations.