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Related Experiment Videos

Nitrofurantoin not surface active agent in rabbit urinary bladder.

M R Ruggieri, P M Hanno, R M Levin

    Urology
    |May 1, 1987
    PubMed
    Summary
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    Nitrofurantoin does not damage the bladder

    Area of Science:

    • Urology
    • Pharmacology

    Background:

    • The bladder's glycosaminoglycan (GAG) layer prevents bacterial adherence.
    • Nitrofurantoin has been hypothesized to induce interstitial cystitis by damaging this GAG layer.

    Purpose of the Study:

    • To investigate if nitrofurantoin, at high concentrations, damages the bladder's GAG layer.
    • To assess nitrofurantoin's effect on bacterial adherence compared to known surfactants.

    Main Methods:

    • Exposure of the bladder lumen to nitrofurantoin (at >2x therapeutic concentration), Triton X-100, acid, and organic solvents.
    • Evaluation of GAG layer integrity using periodic acid-Schiff histochemistry.
    • Assessment of bacterial adherence post-treatment.

    Main Results:

    Related Experiment Videos

  • Nitrofurantoin did not destroy the bladder GAG layer or increase bacterial adherence.
  • Triton X-100, acid, and most organic solvents (except 50% DMSO) removed the GAG layer and increased bacterial adherence.
  • 50% DMSO did not affect the GAG layer or bacterial adherence.

    • Conclusions:

    • Nitrofurantoin does not act as a surfactant agent damaging the bladder GAG layer.
    • Nitrofurantoin is unlikely to cause interstitial cystitis symptoms through surfactant activity.
    • These findings suggest nitrofurantoin is safe for the bladder surface regarding GAG integrity.