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The role of ERK-1 and ERK-2 gene polymorphisms in PCOS pathogenesis

Gurhan Guney1, Mine Islimye Taşkın2, Nazli Sener2

  • 1Department of Reproductive Endocrinology and Infertility, Balikesir University Medical Faculty, Cagis Yerleskesi,Bigadic Yolu 17.km, 10145, Balıkesir, Turkey. gurhanguney@yahoo.com.

Reproductive Biology and Endocrinology : RB&E
|June 29, 2022
PubMed
Abstract

Insights

Polycystic ovary syndrome (PCOS) is linked to genetic variations in extracellular signal-regulated kinase (ERK) genes. Specific ERK-1 and ERK-2 gene polymorphisms correlate with PCOS and associated metabolic and hormonal markers.

Area of Science:

  • Endocrinology
  • Genetics
  • Reproductive Medicine

Background:

  • Ovulation is regulated by extracellular signal-regulated kinase-1 (ERK-1) and ERK-2 signaling pathways.
  • Defective ERK signaling contributes to ovulatory and metabolic issues in polycystic ovary syndrome (PCOS).

Purpose of the Study:

  • To investigate ERK-1 and ERK-2 gene polymorphisms in PCOS for the first time in the Turkish population.
  • To determine the association between these polymorphisms and PCOS-related clinical and biochemical parameters.

Main Methods:

  • A case-control study included 102 PCOS patients and 102 healthy controls.
  • Genotyping of ERK-2 rs2276008 and ERK-1 rs11865228 single nucleotide polymorphisms (SNPs) was performed using real-time PCR.
  • Clinical parameters (BMI, Ferriman-Gallwey score, waist-to-hip ratio) and biochemical markers (lipid profile, CRP, total testosterone, HOMA-IR) were assessed.

Main Results:

  • Significant differences in ERK-1 and ERK-2 genotypes were observed between PCOS patients and controls.
  • In PCOS patients, ERK-1 GA and ERK-2 GC genotypes were associated with variations in BMI, FGS, HOMA-IR, CRP, total testosterone, and total cholesterol.

Conclusions:

  • ERK-1 and ERK-2 genes play a role in the pathogenesis of PCOS.
  • Heterozygote polymorphic types of ERK-1 and ERK-2 genes are related to BMI, FGS, HOMA-IR, and CRP levels in PCOS.
Keywords:
ERK-1ERK-2Genetic polymorphismPCOS

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