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Updated: Sep 6, 2025
Noninvasive Electrocardiography in the Perinatal Mouse
Published on: June 12, 2020
Model-based estimation of QT intervals of mouse fetal electrocardiogram
Namareq Widatalla1, Kiyoe Funamoto2, Motoyoshi Kawataki3
1School of Medicine, Tohoku University, 2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi, 980-8575, Japan. namareq.widatalla@gmail.com.
Background:
Abnormal prolongation in the QT interval or long QT syndrome (LQTS) is associated with several cardiac complications such as sudden infant death syndrome (SIDS). LQTS is believed to be linked to genetic mutations which can be understood by using animal models, such as mice models. Nevertheless, the research related to fetal QT interval in mice is still limited because of challenges associated with T wave measurements in fetal electrocardiogram (fECG). Reliable measurement of T waves is essential for estimating their end timings for QT interval assessment.
Results:
A mathematical model was used to estimate QT intervals. Estimated QT intervals were validated with Q-aortic closure (Q-Ac) intervals of Doppler ultrasound (DUS) and comparison between both showed good agreement with a correlation coefficient higher than 0.88 (r > 0.88, P < 0.05).
Conclusion:
Model-based estimation of QT intervals can help in better understanding of QT intervals in fetal mice.
