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Single-pill fixed-dose drug combinations to reduce blood pressure: the right pill for the right patient

Riccardo Sarzani1, Giorgia Laureti2, Alessandro Gezzi2

  • 1Internal Medicine and Geriatrics, 'Hypertension Excellence Centre' of the European Society of Hypertension, IRCCS, INRCA, via della Montagnola 81, 60127 Ancona, Italy.

Therapeutic Advances in Chronic Disease
|June 30, 2022
PubMed

Insights

Managing arterial hypertension effectively requires sustained blood pressure reduction. This review guides physicians in selecting optimal single-pill fixed-dose combinations for personalized cardiovascular risk management.

Area of Science:

  • Cardiology
  • Pharmacology
  • Internal Medicine

Background:

  • Arterial hypertension is a leading global cause of cardiovascular morbidity and mortality.
  • Effective blood pressure reduction is crucial for mitigating cardiovascular risk.

Purpose of the Study:

  • To guide clinicians in selecting appropriate single-pill fixed-dose combinations (SP-FDCs) for hypertension management.
  • To align SP-FDC selection with individual patient phenotypes and cardiovascular risk profiles.

Main Methods:

  • This is a practical narrative review.
  • Focuses on clinical decision-making for SP-FDC selection in daily practice.

Main Results:

  • Single-pill fixed-dose combinations offer a valuable therapeutic strategy.
  • SP-FDCs can enhance treatment adherence and target multiple pathophysiological mechanisms.
  • Personalized selection based on clinical phenotype and risk is emphasized.

Conclusions:

  • Optimizing hypertension treatment involves careful selection of SP-FDCs.
  • Tailoring therapy to the individual patient improves outcomes and cardiovascular risk management.

Keywords:
arterial hypertensioncholesteroldrug therapydyslipidemiafixed-dose combinationhigh blood pressurereview

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