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Updated: Sep 6, 2025

A Porcine Model of Acute Autologous Pulmonary Embolism
Published on: September 6, 2024
Two is not always better than one: ST-segment elevation myocardial infarction and acute pulmonary embolism in
Avinash Radhakrishna1, Mohammed Omar Abdelaziz1, Niall Mulvihill1
1Department of Cardiology, St. Vincent's University Hospital, Dublin 4, Ireland.
Insights
Severe COVID-19 can cause heart attack and blood clots in healthy individuals. Prompt treatment including blood clot removal and anticoagulation led to recovery.
Area of Science:
- Cardiology
- Infectious Diseases
- Pulmonology
Background:
- Coronavirus disease 2019 (COVID-19) presents a global health challenge with known cardiovascular implications.
- Understanding the multifaceted impact of COVID-19 on the cardiovascular system is crucial for patient management.
Observation:
- A case study of a previously healthy male diagnosed with severe COVID-19 pneumonitis.
- The patient presented with ST-segment elevation myocardial infarction and pulmonary embolism.
Findings:
- COVID-19 can induce a prothrombotic state through hyperinflammatory immune responses and direct endothelial damage.
- Cytokine storm associated with COVID-19 can lead to endothelial dysfunction and subsequent thromboembolic events.
- Successful recovery was achieved through coronary thromboaspiration and anticoagulation therapy.
Implications:
- Highlights the potential for severe cardiovascular complications in COVID-19 patients, even those without prior risk factors.
- Emphasizes the importance of recognizing and managing cardio-pulmonary sequelae of COVID-19.
- Underscores the need for vigilance regarding cardiovascular complications as new COVID-19 variants emerge.
Abstract:
Coronavirus disease 2019 (COVID-19) has become a significant global health burden with potential consequences on the cardiovascular system. We describe a case of a healthy male with no prior cardiovascular risk factors who developed ST-segment elevation myocardial infarction and pulmonary embolism following a diagnosis of severe COVID-19 pneumonitis. The patient made a significant recovery following coronary thromboaspiration and anticoagulation therapy. Multiple mechanisms including an indirect hyperinflammatory immune response and/or direct endothelial damage may explain the prothrombotic state related to COVID-19. The cytokine storm leads to endothelial dysfunction and subsequent thromboembolism. Awareness of the lethal cardio-pulmonary sequalae of COVID-19 is important as surges continue across the world owing to new variants.
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