Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Motor Unit Stimulation

Motor Unit Stimulation

When the neuron of a motor unit fires an action potential, it triggers a series of events, leading to a twitch contraction in the muscle fibers. The process of excitation-contraction coupling is crucial in relaying the action potential to the muscle fibers.
The latent period of contraction marks the onset of excitation-contraction coupling, when the action potential propagates across the sarcolemma, preparing the muscle fibers for contraction. As the fibers enter the contraction phase, the...

Long-term Potentiation

Long-term Potentiation

Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Preflavour and postflavour ban oral nicotine pouches: a chemical, sensory and young adult appeal analysis.

Tobacco control·2026

Same author

A composite measure of cerebral small vessel disease predicts cognitive change after stroke.

medRxiv : the preprint server for health sciences·2026

Same author

CALM-VLM: CALIBRATION AND SELECTIVE PREDICTION IN VISION-LANGUAGE MODELS FOR RELIABLE BRAIN MRI CLASSIFICATION.

bioRxiv : the preprint server for biology·2026

Same author

A Streamlined 4-item Wolf Motor Function Test for Efficient Assessment of Upper Extremity Motor Function in Chronic Stroke Survivors.

Neurorehabilitation and neural repair·2026

Same author

Towards AI-based precision rehabilitation via contextual model-based reinforcement learning.

Journal of neuroengineering and rehabilitation·2025

Same author

Collaborative AI for precision neurorehabilitation: a roadmap.

Journal of neuroengineering and rehabilitation·2025

Search research articles

Related Experiment Video

Updated: Sep 6, 2025

Study Motor Skill Learning by Single-pellet Reaching Tasks in Mice

Study Motor Skill Learning by Single-pellet Reaching Tasks in Mice

Published on: March 4, 2014

Different Patterns of Neural Activity Characterize Motor Skill Performance During Acquisition and Retention.

Dorsa Beroukhim-Kay^1,2,3, Bokkyu Kim^1,4, John Monterosso^2,5

¹Motor Behavior and Neurorehabilitation Laboratory, Division of Biokinesiology and Physical Therapy, Herman Ostrow School of Dentistry, University of Southern California, Los Angeles, CA, United States.

Frontiers in Human Neuroscience

|June 30, 2022

Summary

This summary is machine-generated.

Brain activity during practice differs for performance improvement versus recall. Motor performance relies on cortical and subcortical regions, while skill recall primarily involves prefrontal and motor cortices.

Keywords:

fMRI motor learning neural mechanisms neuroplasticity skill acquisition skill retention

More Related Videos

Acquisition of a High-precision Skilled Forelimb Reaching Task in Rats

Acquisition of a High-precision Skilled Forelimb Reaching Task in Rats

Published on: June 22, 2015

Using Virtual Reality to Transfer Motor Skill Knowledge from One Hand to Another

Using Virtual Reality to Transfer Motor Skill Knowledge from One Hand to Another

Published on: September 18, 2017

Related Experiment Videos

Last Updated: Sep 6, 2025

Study Motor Skill Learning by Single-pellet Reaching Tasks in Mice

Study Motor Skill Learning by Single-pellet Reaching Tasks in Mice

Published on: March 4, 2014

Acquisition of a High-precision Skilled Forelimb Reaching Task in Rats

Acquisition of a High-precision Skilled Forelimb Reaching Task in Rats

Published on: June 22, 2015

Using Virtual Reality to Transfer Motor Skill Knowledge from One Hand to Another

Using Virtual Reality to Transfer Motor Skill Knowledge from One Hand to Another

Published on: September 18, 2017

Area of Science:

Neuroscience
Motor Learning
Cognitive Science

Background:

Motor learning involves distinct mechanisms like error-based, reinforcement, cognitive, and use-dependent learning, each linked to specific brain regions.
Understanding neural circuits for practice improvement versus recall is crucial for motor skill acquisition.

Purpose of the Study:

To investigate brain activity patterns associated with trial-by-trial performance improvement during practice.
To identify neural regions predictive of immediate recall performance after practice.
To differentiate neural mechanisms underlying motor performance and motor skill recall.

Main Methods:

Functional magnetic resonance imaging (fMRI) and behavioral measures (time-on-target, self-efficacy) were used during a pinch force tracking task.
Whole-brain analysis examined correlations between brain activation and performance during practice.
Identified brain regions associated with both performance improvement and immediate retention.

Main Results:

Brain activations in frontal orbital cortex, putamen, amygdala, and insula correlated with practice performance improvement.
Distinct regions, including primary motor cortex, superior frontal gyrus, and somatosensory cortex, were associated with immediate recall performance.
Motor performance improvement engaged cortical and subcortical areas, whereas recall primarily involved prefrontal and motor cortices.

Conclusions:

Improved practice performance and recall of sensorimotor skills are linked to distinct neural activity patterns.
Motor performance improvement and skill recall engage different motor learning mechanisms.
Findings may inform interventions to enhance motor skill learning and retention.