Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Border disease without nervous signs or fleece changes.

M A Bonniwell, P F Nettleton, A C Gardiner

    The Veterinary Record
    |March 14, 1987
    PubMed
    Summary

    A border disease virus outbreak in Argyll presented atypically with abortions and weak lambs, not typical tremors or fleece changes. Persistent infection in purchased sheep introduced the virus, highlighting challenges in natural disease control.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Herpesvirus infection in Cervidae.

    Revue scientifique et technique (International Office of Epizootics)·2020
    Same author

    Prevalence of antibodies to bovine viral diarrhoea virus in bulk tank milk and associated risk factors in Scottish dairy herds.

    The Veterinary record·2012
    Same author

    A subset of Binet stage A CLL patients with TP53 abnormalities and mutated IGHV genes have stable disease.

    Leukemia·2008
    Same author

    Atypical bovine herpes mammillitis affecting cows and calves.

    The Veterinary record·2008
    Same author

    A novel functional assay using etoposide plus nutlin-3a detects and distinguishes between ATM and TP53 mutations in CLL.

    Leukemia·2008
    Same author

    Antiviral activity of HPMPC (cidofovir) against orf virus infected lambs.

    Antiviral research·2006

    Area of Science:

    • Veterinary Virology
    • Sheep Pathology

    Background:

    • Border disease virus (BDV) infection in sheep flocks can cause significant economic losses.
    • Typical clinical signs include tremors and fleece abnormalities, but atypical presentations can occur.

    Purpose of the Study:

    • To investigate an unusual outbreak of border disease in a sheep flock.
    • To identify the source and transmission dynamics of the BDV infection.
    • To evaluate the effectiveness of natural exposure for inducing immunity.

    Main Methods:

    • Epidemiological investigation of a sheep flock experiencing abortions and lamb mortality.
    • Detection of BVDV viraemia in lambs and purchased ewes.
    • Attempted natural vaccination by co-mingling susceptible sheep with infected animals.

    Related Experiment Videos

    Main Results:

    • The outbreak was linked to four persistently infected ewes introduced to the flock.
    • Clinical signs were limited to abortion and birth of small, weak lambs, lacking typical neurological or fleece signs.
    • Natural vaccination attempt was largely unsuccessful, with low seroconversion rates in sentinel sheep.
    • Removal of infected animals led to disease cessation and improved lambing percentages in the subsequent year.
    • Persistently infected ewes produced healthy but persistently infected lambs.

    Conclusions:

    • Persistent BDV infection in purchased sheep can introduce the virus without obvious clinical signs in adults.
    • Atypical presentations of BDV, focusing on reproductive losses, can occur.
    • Natural vaccination strategies by co-mingling are unreliable for controlling BDV.
    • Strict biosecurity and removal of persistently infected animals are crucial for disease control.