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Effective Primary Prevention of Atopic Dermatitis in High-Risk Neonates via Moisturizer Application: Protocol for a

Yusuke Inuzuka1, Kiwako Yamamoto-Hanada1, Kyongsun Pak2

  • 1Allergy Center, National Center for Child Health and Development, Tokyo, Japan.

Frontiers in Allergy
|June 30, 2022
PubMed

Insights

Twice daily application of Fam's Baby™ moisturizer may be more effective than once daily application for preventing atopic dermatitis (AD) in infants. This study compares Fam's Baby™ and 2e moisturizers to find optimal prevention strategies.

Area of Science:

  • Dermatology
  • Neonatal Care
  • Clinical Trials

Background:

  • Atopic dermatitis (AD) is a chronic inflammatory skin condition impacting infant quality of life.
  • Previous findings on moisturizer 2e for AD prevention are inconsistent, necessitating further research.
  • Optimal moisturizer type and application frequency for infant AD prevention remain undetermined.

Purpose of the Study:

  • To compare the efficacy of twice daily versus once daily application of Fam's Baby™ moisturizer.
  • To evaluate once daily application of 2e moisturizer as a control.
  • To determine the optimal moisturizer regimen for preventing AD in neonates and infants.

Main Methods:

  • A single-center, phase II, randomized controlled trial involving 60 newborns.
  • Participants are assigned to one of three groups: Fam's Baby™ twice daily, Fam's Baby™ once daily, or 2e once daily.
  • The primary outcome is the time to the first onset of AD.

Main Results:

  • This section is not available in the provided abstract.
  • Further research is needed to determine the efficacy of different moisturizer application frequencies.
  • The study aims to inform future phase III trials for definitive conclusions.

Conclusions:

  • This trial is the first in Japan to assess Fam's Baby™ for AD prevention in infants.
  • Results will guide a potential phase III study on optimal AD prevention through moisturizers.
  • The study anticipates contributing to reduced AD prevalence and healthcare costs.
Abstract

Keywords:
atopic dermatitiscontrolled trialmoisturizerneonaterandomized

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