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Comparative Evaluation between the LaxaPlus Barij® and Polyethylene Glycol (4000) in the Pediatric Functional

Peiman Nasri1,2, Shima Saeidi1, Hosein Saneian1,2

  • 1Metabolic Liver Disease Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.

Journal of Research in Pharmacy Practice
|June 30, 2022
PubMed

Insights

LaxaPlus Barij® and polyethylene glycol (4000) effectively treat pediatric functional constipation. LaxaPlus Barij® showed greater improvement in bowel movement frequency and reduced pain compared to polyethylene glycol.

Area of Science:

  • Pediatric Gastroenterology
  • Clinical Pharmacology
  • Digestive Health

Background:

  • Functional constipation is a common pediatric gastrointestinal disorder.
  • Treatment options for pediatric constipation include osmotic laxatives.
  • Comparing the efficacy and safety of different laxatives is crucial for optimal patient care.

Purpose of the Study:

  • To compare the efficacy of LaxaPlus Barij® and polyethylene glycol (4000) in treating functional constipation in children aged 2-15 years.
  • To evaluate outcomes such as stool consistency, bowel movement frequency, and pain intensity.
  • To assess patient satisfaction with both treatments.

Main Methods:

  • A randomized clinical trial involving 60 children diagnosed with functional constipation.
  • Participants were assigned to receive either LaxaPlus Barij® or polyethylene glycol (4000).
  • Data were analyzed using SPSS software with a significance level of P < 0.05.

Main Results:

  • Both treatments significantly improved stool consistency and increased bowel movement frequency in children.
  • LaxaPlus Barij® demonstrated a significantly higher number of bowel movements compared to polyethylene glycol.
  • No significant differences were observed in demographic characteristics between the treatment groups.

Conclusions:

  • Both LaxaPlus Barij® and polyethylene glycol (4000) are effective in treating pediatric functional constipation.
  • LaxaPlus Barij® showed superior effectiveness in increasing bowel movement frequency and reducing pain intensity after 8 weeks.
  • Patient satisfaction levels were comparable between the two treatment groups.
Abstract

Keywords:
ChildLaxaPlus Barij®constipationpolyethylene glycol

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