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Related Experiment Video

Updated: Sep 6, 2025

Mouse Kidney Transplantation: Models of Allograft Rejection

Mouse Kidney Transplantation: Models of Allograft Rejection

Published on: October 11, 2014

Educational Case: Renal allograft rejection.

Harrison Dai¹, Shirui Chen², Jolanta Kowalewska¹

¹Department of Pathology and Anatomy, Eastern Virginia Medical School, Norfolk, VA, USA.

Academic Pathology

|June 30, 2022

Summary

This summary is machine-generated.

Chronic rejection is a slow transplant rejection process occurring over months to years. It involves immune cells and antibodies attacking donor organs, leading to fibrosis and vascular damage.

Keywords:

Disease mechanisms Human leukocyte antigen Immune dysfunction Immunological mechanisms Pathology competencies Rejection Transplantation

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Last Updated: Sep 6, 2025

Mouse Kidney Transplantation: Models of Allograft Rejection

Mouse Kidney Transplantation: Models of Allograft Rejection

Published on: October 11, 2014

A Rat Orthotopic Renal Transplantation Model for Renal Allograft Rejection

A Rat Orthotopic Renal Transplantation Model for Renal Allograft Rejection

Published on: February 2, 2022

Orthotopic Rat Kidney Transplantation: A Novel and Simplified Surgical Approach

Orthotopic Rat Kidney Transplantation: A Novel and Simplified Surgical Approach

Published on: May 7, 2019

Area of Science:

Transplantation immunology
Pathology of organ transplant rejection

Background:

Chronic rejection is the slowest form of transplant rejection, manifesting months to years post-transplant.
Its pathogenesis involves complex cell- and humoral-mediated immune responses targeting donor antigens.

Purpose of the Study:

To elucidate the pathological mechanisms and characteristic findings of chronic transplant rejection.

Main Methods:

Histopathological analysis of chronically rejected transplants.
Identification of immune cell infiltrates and antibody-mediated damage markers.

Main Results:

Chronic rejection presents with nonspecific findings including interstitial fibrosis and tubular atrophy.
Vascular changes show intimal thickening with macrophages and lymphocytes.
Transplant glomerulopathy involves mesangial expansion and capillary wall changes.

Conclusions:

Chronic rejection is characterized by distinct histopathological features indicative of ongoing immune attack.
Understanding these findings is crucial for diagnosing and managing long-term transplant outcomes.