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Related Experiment Video

Updated: Sep 6, 2025

Implantation and Evaluation of Melanoma in the Murine Choroid via Optical Coherence Tomography

Implantation and Evaluation of Melanoma in the Murine Choroid via Optical Coherence Tomography

Published on: December 2, 2022

Primary intestinal melanoma?

Angie Gómez-Uranga¹, Pedro Jesús Esteve-Atiénzar², Antonio López-Jiménez³

¹Medicina Interna , Hospital Universitario San Juan de Alicante, España.

Revista Espanola De Enfermedades Digestivas

|June 30, 2022

Summary

Malignant melanomas in the small intestine are usually metastatic. This case highlights a rare instance of primary ileal melanoma in a patient with a history of cutaneous melanoma, prompting discussion on neoplasm origins.

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A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis

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Area of Science:

Gastroenterology
Oncology
Pathology

Background:

Malignant melanomas in the small intestine are predominantly metastatic from cutaneous sources.
Primary small intestinal melanomas are exceptionally rare, with some debate regarding their true incidence versus occult metastatic disease.

Observation:

A 77-year-old woman with a prior history of cutaneous melanoma excision 38 years earlier presented with iron deficiency anemia.
Diagnostic workup revealed an ileal melanoma without evidence of other melanoma lesions.

Findings:

The patient was diagnosed with primary ileal melanoma, challenging the notion that all small intestinal melanomas are metastatic.
The long latency period between the initial melanoma excision and the ileal diagnosis is notable.

Implications:

This case contributes to the understanding of rare gastrointestinal neoplasms.
It underscores the importance of considering primary origins for small intestinal melanomas, even in patients with a history of cutaneous melanoma.
Further research into the pathogenesis of primary gastrointestinal melanomas is warranted.