Related Experiment Video
Updated: Sep 6, 2025

Real-Time Cardiac Mapping with a Noninvasive Imageless Electrocardiographic Imaging System
Published on: April 11, 2025
The De Winter-like electrocardiogram pattern associated with multi-vessel disease
Chunfang Wang1, Hongli Yan1, Jian Wang1
1Department of Cardiology, Binzhou Medical University Hospital, Binzhou City, China.
Insights
The de Winter ECG pattern, linked to Left Anterior Descending artery occlusion, was observed in a patient with multivessel coronary artery disease. This case highlights the pattern
Area of Science:
- Cardiology
- Electrocardiography
- Interventional Cardiology
Background:
- The de Winter electrocardiogram (ECG) pattern is characterized by specific ST-segment and T-wave abnormalities.
- This pattern has been historically associated with acute occlusion of the Left Anterior Descending (LAD) artery.
Observation:
- A case study involving a patient presenting with chest pain and the de Winter ECG pattern.
- The patient's 12-lead ECG exhibited upsloping ST-segment depression in anterior leads (V2-V6), tall symmetrical T waves in V2-V4, J point elevation in aVR, and ST depression in lateral leads.
- The ECG findings were consistent with the de Winter pattern.
Findings:
- Coronary angiography revealed significant stenosis in the LAD (60-80%) and Right Coronary Artery (RCA) (50-60% ostial, 90% mid-segment).
- The patient had multivessel coronary artery disease, not solely LAD occlusion.
- Percutaneous coronary intervention with drug-eluting stents was successfully performed on the RCA lesions.
Implications:
- The de Winter ECG pattern may indicate multivessel coronary artery disease, extending beyond isolated LAD occlusion.
- This case underscores the importance of comprehensive ECG interpretation in patients with acute coronary syndromes.
- Recognition of this pattern can guide timely diagnostic and therapeutic interventions in complex coronary artery disease scenarios.
Background:
The de Winter ECG pattern was described by upsloping ST-segment depression in leads V1-V6, tall and symmetrical T waves in precordial leads. The ECG pattern is regarded to be associated with occlusion of the left anterior descending (LAD) artery.
Methods:
One patient with de Winter ECG pattern was included. The 12-lead ECG of patients with chest pain showed upsloping ST-segment depression up to 3 mm at the J point in leads V2-V6; tall symmetrical T waves in leads V2-V4; 1mm J point elevation in lead aVR; ST-segment depression 1mm in I, aVL leads and inverted T waves in the inferior leads. The ECG was showed the de Winter pattern.
Results:
The ECG was showed the de Winter pattern. CAG was performed, which showed the normal left main; 60%-80% LAD stenosis; 50%-60% ostial right coronary artery(RCA) stenosis; and 90% stenosis of the vessel at middle segment. Both proximal and middle RCA vascular lesions were dilated and successfully inserted with drug-eluting stents, respectively.
Conclusion:
Our case the ECG was showed horizontal ST depression with tall T waves in leads V2-V4 (maximal ST depression in lead V4) while only ST depression in leads V5-V6, which may result from multivessel disease.
More Related Videos
06:57Ablation of Ischemic Ventricular Tachycardia Using a Multipolar Catheter and 3-dimensional Mapping System for High-density Electro-anatomical Reconstruction
Published on: January 31, 2019
18:11A Research Method For Detecting Transient Myocardial Ischemia In Patients With Suspected Acute Coronary Syndrome Using Continuous ST-segment Analysis
Published on: December 28, 2012
Related Concept Videos
Electrocardiogram
Three major waveforms are present in a typical ECG recording: the P wave, the QRS complex, and...
ECG Interpretation of Arrhythmias II: Atrial, Junctional and Ventricular Arrhythmias
Dysrhythmias III: Characteristics of Dysrhythmias
Electrocardiogram Fundamentals
An electrocardiogram (ECG) is a diagnostic tool for identifying cardiac conditions such as arrhythmias, conduction abnormalities, and myocardial ischemia.
Definition
An electrocardiogram (ECG) visualizes the heart's electrical activity by tracing the electrical movement associated with each heartbeat on a graph or monitor. As the heart beats, an electrical wave passes through it, correlating with the cardiac cycle events.
Parts of an ECG
An ECG utilizes electrodes on the skin...
Cardiomyopathy IV: Restrictive Cardiomyopathy
Coronary Artery Disease III: Clinical Manifestations