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Chemerin Levels in Acute Coronary Syndrome: Systematic Review and Meta-Analysis

Abdulrahman Ismaiel1, Mohammad Zeeshan Ashfaq2, Daniel-Corneliu Leucuta3

  • 12nd Department of Internal Medicine, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania.

Laboratory Medicine
|June 30, 2022
PubMed

Insights

Chemerin levels are significantly higher in acute coronary syndrome (ACS) patients, particularly those with type 2 diabetes mellitus (T2DM). No significant difference was found between ACS and stable angina patients.

Area of Science:

  • Cardiology
  • Biochemistry
  • Medical Research

Background:

  • Acute coronary syndromes (ACS) represent a significant global health burden.
  • Biomarkers for risk stratification and diagnosis in ACS are crucial.
  • Chemerin, a pro-inflammatory adipokine, has been implicated in cardiovascular disease.

Approach:

  • A systematic literature search was conducted across major databases (PubMed, Scopus, Embase, Cochrane Library) in October 2021.
  • Six relevant studies were identified for the systematic review.
  • Five studies were included in the meta-analysis, with quality assessed using the Newcastle-Ottawa score.

Key Points:

  • Chemerin levels were significantly elevated in ACS patients compared to control subjects (MD 41.69 ng/mL).
  • Chemerin levels were significantly elevated in type 2 diabetes mellitus (T2DM) ACS patients versus nondiabetic ACS patients (MD 62.10 ng/mL).
  • No significant difference in chemerin levels was observed between ACS patients and stable angina pectoris (SAP) patients (MD 132.14 ng/mL).

Conclusions:

  • Chemerin is a potential biomarker for elevated risk in ACS.
  • Elevated chemerin levels are associated with ACS, especially in patients with T2DM.
  • Chemerin may not be a distinguishing biomarker between ACS and SAP.
Abstract

Keywords:
acute coronary syndromechemerincoronary artery diseasediabetes mellitusischemic heart diseasestable angina pectoris

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