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Related Concept Videos

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Related Experiment Video

Updated: May 11, 2026

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Spatially Patterned Neutralizing Icosahedral DNA Nanocage for Efficient SARS-CoV-2 Blocking.

Jialu Zhang1,2, Yunyun Xu2, Yihao Huang1

  • 1The MOE Key Laboratory of Spectrochemical Analysis and Instrumentation, the Key Laboratory of Chemical Biology of Fujian Province, State Key Laboratory of Physical Chemistry of Solid Surfaces, Department of Chemical Biology, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China.

Journal of the American Chemical Society
|June 30, 2022
PubMed
Summary

A novel icosahedral DNA framework (IDNA-30) assembles neutralizing aptamers to combat SARS-CoV-2. This broad-spectrum strategy effectively inhibits wild-type and mutant strains, including Omicron, by blocking viral infection.

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Area of Science:

  • Nanotechnology
  • Virology
  • Biochemistry

Background:

  • The global threat of SARS-CoV-2 necessitates broad-spectrum antiviral strategies.
  • Existing treatments face challenges with emerging viral strains and mutations.

Purpose of the Study:

  • To develop a novel nanostructure for assembling neutralizing aptamers against SARS-CoV-2.
  • To create a broad-spectrum antiviral agent capable of inhibiting diverse viral strains.

Main Methods:

  • Design and assembly of an icosahedral DNA framework (IDNA-30) presenting up to 30 spatially arranged aptamers.
  • Topological matching of aptamers to the SARS-CoV-2 spike protein trimer for multivalent binding.
  • Utilizing the framework's rigidity and aptamer arrangement to induce viral aggregation and block host cell entry.

Main Results:

  • IDNA-30 demonstrated effective broad-spectrum neutralization of SARS-CoV-2.
  • The nanostructure successfully inhibited wild-type and mutant strains, including Omicron pseudovirus.
  • Multivalent, spatially patterned aptamer binding induced viral aggregation and blocked infection.

Conclusions:

  • IDNA-30 represents a promising multidimensional neutralizing strategy against SARS-CoV-2.
  • This approach enhances the inhibitory effect of neutralizing reagents for combating viral infections.
  • The framework offers a new direction for developing antiviral therapies against current and future viruses.