State of the Art: Quantitative Cardiac MRI in Cardiac Amyloidosis
Yubo Guo1, Xiao Li1, Yining Wang1
1Department of Radiology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China.
Insights
Cardiac amyloidosis (CA) is often missed. Quantitative cardiac MRI offers advanced imaging to detect early CA, improving patient diagnosis and management for better outcomes.
Area of Science:
- Cardiology
- Medical Imaging
- Biomedical Engineering
Background:
- Cardiac amyloidosis (CA) involves amyloid buildup in the heart, leading to heart failure and underdiagnosis.
- Cardiac involvement significantly impacts prognosis and treatment decisions in CA patients.
- Early detection and accurate patient stratification are vital for managing CA.
Purpose of the Study:
- To review quantitative cardiac MRI techniques for assessing cardiac amyloidosis.
- To highlight established and emerging methods for evaluating CA using cardiac MRI.
- To discuss the role of quantitative MRI in understanding CA and personalizing patient care.
Main Methods:
- Utilizing comprehensive cardiac MRI to evaluate cardiac structure and function.
- Employing myocardial tissue characterization to trace disease progression in CA.
- Applying emerging quantitative techniques for early CA identification and monitoring treatment response.
Main Results:
- Quantitative cardiac MRI provides new measures for early CA detection.
- Advanced MRI techniques enable monitoring of disease progression and treatment efficacy.
- Cardiac MRI is instrumental in understanding CA and guiding individualized patient care.
Conclusions:
- Quantitative cardiac MRI is crucial for diagnosing and managing cardiac amyloidosis.
- Emerging MRI techniques enhance the ability to identify early-stage CA.
- This imaging modality is transforming patient care for individuals with CA.
Abstract:
Cardiac amyloidosis (CA) is characterized by amyloid infiltration in the myocardial extracellular space, causing heart failure. Patients with CA are currently underdiagnosed. Cardiac involvement is significantly associated with the prognosis and treatment decision-making for CA. Early identification and accurate stratification are the crucial first step in patient management. Comprehensive cardiac MRI-based evaluation of the cardiac structure, function, and myocardial tissue characterization assesses cardiac involvement by tracing disease processes. Emerging quantitative tissue characterization techniques have introduced new measures that can identify early staged CA and monitor disease progression or response after treatment. Quantitative cardiac MRI is becoming an instrumental tool in understanding CA, which leads to changes in individualized patient care. This review aimed to discuss the quantitative cardiac MRI-based assessment of CA using established and emerging techniques. EVIDENCE LEVEL: 5 TECHNICAL EFFICACY: Stage 3.
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