Imaging Features of Breast Plasmacytoma

Area of Science:

• Oncology
• Pathology
• Radiology

Background:

• Extramedullary plasmacytoma (EMP) is a rare plasma cell neoplasm occurring outside the bone marrow.
• Breast involvement by EMP is exceptionally uncommon and can mimic other breast lesions radiologically.
• Accurate diagnosis is vital as EMP management differs from other breast masses and can indicate multiple myeloma (MM) relapse.

Purpose of the Study:

• To present the imaging and clinicopathological findings of an extramedullary plasmacytoma in the breast.
• To highlight the diagnostic challenges and clinical significance of breast EMP, particularly in patients with a history of multiple myeloma.

Main Methods:

• Case report of a 65-year-old patient with a history of multiple myeloma in remission.
• Review of imaging findings (e.g., mammography, ultrasound, MRI) of the breast masses.
• Correlation of imaging findings with histopathological examination and clinical presentation.

Main Results:

• The patient presented with palpable breast masses.
• Radiological evaluation showed lesions that could be mistaken for benign or malignant breast tumors.
• Histopathological analysis confirmed extramedullary plasmacytoma.

Conclusions:

• Extramedullary plasmacytoma of the breast is a rare entity that requires careful radiological and pathological assessment.
• Distinguishing breast EMP from other breast lesions is critical for appropriate treatment planning.
• Breast EMP can be an indicator of multiple myeloma relapse, necessitating thorough evaluation and monitoring.