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Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation
Published on: February 26, 2013
Metabolic effects of the left atrial appendage exclusion (the heart hormone study)
Krzysztof Bartus1,2, Mehmet A Elbey3, Sri Harsha Kanuri3
1Department of Cardiovascular Surgery and Transplantology, Medical College, John Paul Hospital, Jagiellonian University, Krakow, Poland.
Insights
Epicardial left atrial appendage occlusion in atrial fibrillation patients significantly altered insulin, leptin, and adiponectin levels long-term. Lipid and glucose metabolism remained largely unchanged after the procedure.
Area of Science:
- Cardiology
- Metabolic Research
Background:
- Long-term effects of epicardial left atrial appendage (LAA) occlusion on metabolism in atrial fibrillation (AF) patients are not well understood.
- AF is associated with cardiovascular risk factors, making metabolic monitoring crucial.
Purpose of the Study:
- To investigate the long-term impact of epicardial LAA occlusion on lipid and glucose metabolism in AF patients.
- To evaluate changes in key metabolic markers following the procedure.
Main Methods:
- A prospective observational study included 60 AF patients undergoing epicardial LAA exclusion.
- Metabolic parameters including glucose, HbA1c, insulin, leptin, adiponectin, and lipids were measured at baseline and up to 24 months post-procedure.
Main Results:
- Insulin levels significantly increased at multiple follow-up points up to 24 months.
- Leptin levels showed a significant increase at 6, 12, and 24 months, while adiponectin levels significantly decreased.
- No significant changes were observed in glucose, HbA1c, total cholesterol, or beta-hydroxybutyrate levels at 24 months.
Conclusions:
- Epicardial LAA occlusion is associated with significant long-term alterations in insulin, leptin, and adiponectin levels in AF patients.
- The procedure did not significantly affect glucose or lipid metabolism over the 24-month follow-up period.
Introduction:
The effect of epicardial left atrial appendage (LAA) occlusion therapy on lipid and glucose metabolism in atrial fibrillation (AF) patients over the long-term follow-up are unclear.
Methods:
In a single-center prospective observational study, 60 patients with longstanding persistent AF with cardiovascular risk factors had undergone an epicardial exclusion procedure. Anthropometric parameters and glucose, glycated hemoglobin (HbA1c), insulin, leptin, adiponectin, free fatty acids, beta-hydroxybutyrate, and total cholesterol levels were evaluated on fasting at baseline before the procedure and compared with levels at 24 h, 7 days, 1, 3, 6, and 24 months follow the procedure.
Results:
The mean age of the patients was 67.5 ± 8.1. Insulin levels significantly increased at 7 days, 1, 3, 6, 12, and 24 months follow-up. The leptin levels showed a significant increase in 6, 12, and 24 months when compared to baseline. Whereas the adiponectin levels showed a significant decrease at 3, 6, 12, and 24 months when compared to baseline levels. In patients with the epicardial procedure, when compared to baseline, glucose, glycated hemoglobin, total cholesterol, and beta-hydroxybutyrate levels did not show any significant changes at baseline and 24 months follow-up.
Conclusion:
The epicardial exclusion ligation in AF patients was associated with significant changes in insulin, leptin, and adiponectin over long follow-up.
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