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Updated: Sep 6, 2025

Perspectives on Neuroscience

Perspectives on Neuroscience

Published on: July 31, 2007

Recent advances in understanding neuro.

Alban Ziegler¹, Wendy K Chung²

¹Department of Pediatrics, Columbia University Irving Medical Center, New York, NY, USA.

Current Opinion in Genetics & Development

|June 30, 2022

Summary

This summary is machine-generated.

Congenital heart disease (CHD) is linked to neurodevelopmental issues, with genetics playing a key role. Outcomes are complex, influenced by genetic and environmental factors throughout a child's care.

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Area of Science:

Genetics and Developmental Neuroscience
Pediatric Cardiology

Background:

Congenital heart disease (CHD) impacts approximately 1% of global live births.
CHD is frequently associated with diverse neurodevelopmental disorders.
Genetic factors are significantly implicated in adverse neurodevelopmental outcomes in affected children.

Purpose of the Study:

To explore the intricate genetic underpinnings of neurodevelopmental disorders in CHD.
To examine the interplay between genetic factors and various clinical and psychosocial risk factors.

Main Methods:

Review of recent studies on genetic contributions (monogenic, oligogenic, polygenic) to neurodevelopmental outcomes in CHD.
Analysis of the influence of preoperative, perioperative, postoperative, and psychosocial factors.

Main Results:

Genetic complexity, encompassing monogenic, oligogenic, and polygenic factors, significantly shapes neurodevelopmental trajectories.
Interactions between genetic predispositions and a spectrum of clinical and psychosocial factors (e.g., prematurity, surgical interventions, socioeconomic status) are critical.

Conclusions:

Understanding the multifaceted genetic and environmental influences is crucial for predicting and mitigating neurodevelopmental deficits in CHD.
Integrated approaches considering genetic, clinical, and psychosocial elements are essential for comprehensive CHD care and research.