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Updated: Sep 6, 2025

Ex Vivo Analysis of Mechanically Activated Ca2+ Transients in Urothelial Cells
Published on: September 28, 2022
Mechanotransduction in the spotlight of mechano-sensitive channels
Marjorie Guichard1, Sébastien Thomine2, Jean-Marie Frachisse2
1Institute of Cell and Interaction Biology, Heinrich-Heine-University Düsseldorf, Universitätsstraße 1, 40225 Düsseldorf, Germany.
Abstract:
The study of mechanosensitive channels (MS) in living organisms has progressed considerably over the past two decades. The understanding of their roles in mechanosensation and mechanotransduction was consecrated by the awarding of the Nobel Prize in 2021 to A. Patapoutian for his discoveries on the role of MS channels in mechanoperception in humans. In this review, we first summarize the fundamental properties of MS channels and their mode of operation. Then in a second step, we provide an update on the knowledge on the families of MS channels identified in plants and the roles and functions that have been attributed to them.
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