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Nervous system manifestations related to COVID-19 and their possible mechanisms
Zhen Xie1, Hao Hui2, Zhihan Zhao3
1The College of Life Sciences and Medicine, Northwest University, No. 229 Taibai North Road, Xi'an, Shaanxi 710069, PR China; Medical Research Center; Xi'an Key Laboratory of Cardiovascular and Cerebrovascular Diseases, Xi'an No.3 Hospital, the Affiliated Hospital of Northwest University, No.10 Eastern section of the third FengCheng Rd., WeiYang District, Xi'an City, Shaanxi Province, P.R. China.
Abstract:
In December 2019, the novel coronavirus disease (COVID-19) due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection broke. With the gradual deepening understanding of SARS-CoV-2 and COVID-19, researchers and clinicians noticed that this disease is closely related to the nervous system and has complex effects on the central nervous system (CNS) and peripheral nervous system (PNS). In this review, we summarize the effects and mechanisms of SARS-CoV-2 on the nervous system, including the pathways of invasion, direct and indirect effects, and associated neuropsychiatric diseases, to deepen our knowledge and understanding of the relationship between COVID-19 and the nervous system.
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