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Related Concept Videos

Brain Imaging01:14

Brain Imaging

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Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans),  magnetic resonance imaging (MRI),  functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...
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Deep Brain Stimulation with Simultaneous fMRI in Rodents
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An fMRI-compatible system for targeted electrical stimulation.

Louise Møller Jørgensen1, Anders Ohlhues Baandrup2, Joseph Mandeville3

  • 1Neurobiology Research Unit, Department of Neurology, Copenhagen University Hospital - Rigshospitalet, Inge Lehmannsvej 6-8, 2100 Copenhagen, Denmark; Copenhagen Spine Research Unit, Center for Rheumatology and Spine Diseases, Copenhagen University Hospital - Rigshospitalet, Valdemar Hansens Vej 13-17, 2600 Glostrup, Denmark; Department of Clinical Medicine, University of Copenhagen, Blegdamsvej 2, 2200 Copenhagen, Denmark.

Journal of Neuroscience Methods
|June 30, 2022
PubMed
Summary
This summary is machine-generated.

We developed a novel system for fMRI-compatible electrical stimulation, enabling safe and accurate deep brain stimulation (DBS) studies. This technology allows for synchronized experiments and reveals neocortical responses to DBS in pigs.

Keywords:
Deep brain stimulationElectroceutical therapyOptic fiberRF Noise SpectrumRadiofrequency emissionfMRI

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Area of Science:

  • Neuroscience
  • Biomedical Engineering
  • Medical Technology

Background:

  • Neuromodulation is a growing therapeutic field in neuropsychiatry, pain, and rehabilitation.
  • Combining functional Magnetic Resonance Imaging (fMRI) with electrostimulation can elucidate therapeutic mechanisms.
  • Previous research faced technological limitations for safe and accurate concurrent fMRI and electrostimulation studies.

Purpose of the Study:

  • To present a novel system for fMRI-compatible electrical stimulation.
  • To demonstrate its capability in conducting deep brain stimulation (DBS) experiments.
  • To provide proof-of-concept neuroimaging data using the system.

Main Methods:

  • A two-module system connected via optical fiber, synchronized with MRI scanners.
  • Evaluation involved deep brain stimulation (DBS) in the subthalamic nucleus (STN) of four pigs.
  • Blood-oxygen-level-dependent (BOLD) responses were acquired in the STN and neocortex.

Main Results:

  • The system reliably delivered synchronized electrical stimuli during fMRI acquisition.
  • A significant neocortical BOLD response was observed following DBS in the STN.
  • No significant BOLD response was detected within the STN itself.

Conclusions:

  • The developed system overcomes major challenges in combining electrical stimulation with fMRI.
  • It prevents fMRI signal distortion, synchronizes experimental conditions, and ensures safety.
  • This adaptable technology facilitates electroceutical research beyond DBS, including flexible fMRI designs and stimulation parameters.