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Related Experiment Video

Updated: Sep 6, 2025

Full-Endoscopic Surgery for Hypothalamic Hamartoma Resection

Full-Endoscopic Surgery for Hypothalamic Hamartoma Resection

Published on: April 12, 2024

Neuronavigation-Guided Transcortical-Transventricular Endoport-Assisted Endoscopic Resection for Thalamic Lesions:

Shuang Liu¹, Silin Wu¹, Tao Xie¹

¹Department of Neurosurgery, Zhongshan Hospital, Fudan University, Shanghai, China.

World Neurosurgery

|June 30, 2022

Summary

Neuronavigation-guided endoscopic surgery for thalamic lesions is feasible. This approach safely removes benign tumors and may improve survival in select glioblastoma cases.

Keywords:

Endoport Endoscopy Neuronavigation Prognosis Thalamic lesions

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Last Updated: Sep 6, 2025

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Area of Science:

Neurosurgery
Minimally Invasive Techniques
Neuro-oncology

Background:

Thalamic lesions present surgical challenges due to their deep location and proximity to critical neurovascular structures.
The feasibility of neuronavigation-guided transcortical-transventricular endoport-assisted endoscopic resection for thalamic lesions requires further investigation.

Purpose of the Study:

To evaluate the safety and efficacy of neuronavigation-guided transcortical-transventricular endoport-assisted endoscopic resection for thalamic lesions.
To assess outcomes for both benign and malignant thalamic tumors treated with this minimally invasive approach.

Main Methods:

Retrospective review of 8 patients undergoing neuronavigation-guided transcortical-transventricular endoport-assisted endoscopic resection for thalamic lesions.
Analysis of preoperative variables, tumor characteristics, and postoperative outcomes.

Main Results:

The study included lesions of various pathologies (cavernous malformation, pilocytic astrocytomas, glioblastomas) with a median size of 31 mm.
Gross total resection and long-term survival were achieved for benign lesions.
For glioblastomas, near-total resection was achieved in 75% of patients, with one patient remaining recurrence-free at 16 months; however, 3 patients experienced disease progression and mortality within 6 months.

Conclusions:

Neuronavigation, endoscopy, and endoport techniques via the middle frontal gyrus approach enable safe and effective resection of medial thalamic benign lesions.
This technique is applicable to well-selected glioblastoma cases, potentially offering a survival benefit for this aggressive malignancy.