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The road not taken: host genetics in shaping intergenerational microbiomes
Shuqin Zeng1, Shaopu Wang1, R Paul Ross2
1Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, 610041, China; APC Microbiome Ireland, University College Cork, Cork, T12 YT20, Ireland; Teagasc Food Research Centre, Moorepark, Fermoy, Co. Cork, P61 C996, Ireland.
Trends in Genetics : TIG
|June 30, 2022
Summary
Host genetics significantly influence the early-life gut microbiome, impacting health throughout life. Understanding these genetic factors is crucial for future microbiome research and interventions.
Area of Science:
- Microbiology
- Genetics
- Human Health
Background:
- The early-life gut microbiome is critical for lifelong health, with imbalances linked to disease.
- Mechanisms of microbiome acquisition, colonization, and stability in early life remain unclear.
- Host genetics are known to shape the gut microbiome and influence host phenotypes.
Purpose of the Study:
- To explore the role of host genetics in shaping the early-life gut microbiome.
- To discuss the intergenerational transmission of the microbiome from mothers to offspring.
- To examine the bidirectional interactions between host gene expression and the microbiome.
Main Methods:
- Review of current literature on host genetics and early-life microbiome.
- Analysis of studies in human and animal models.
- Discussion of vertical microbial transmission and gene-microbiome interactions.
Main Results:
- Host genetics are a key determinant of early-life gut microbiome composition and variability.
- Intergenerational transmission of the microbiome is influenced by host genetics.
- Bidirectional interactions between host genes and the microbiome affect human health.
Conclusions:
- Host genetics play a fundamental role in establishing the early-life gut microbiome.
- Considering host genetics is essential for future research on early-life microbiome development and health.
- Understanding gene-microbiome interactions offers insights into human health and disease prevention.
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