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Updated: Sep 6, 2025

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
12:45

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

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Utilization and Efficacy of Cardiac Resynchronization Therapy in Patients With Chronic Heart Failure　- A Report From

Hideka Hayashi1, Satoshi Yasuda1, Makoto Nakano1

  • 1Department of Cardiovascular Medicine, Tohoku University Hospital Sendai Japan.

Circulation Reports
|July 1, 2022
PubMed

Insights

Only half of eligible chronic heart failure patients receive cardiac resynchronization therapy (CRT). Older age increases the risk of not receiving CRT, potentially leading to higher mortality and hospital admissions.

Area of Science:

  • Cardiology
  • Medical Devices
  • Heart Failure Management

Background:

  • Cardiac resynchronization therapy (CRT) is established for chronic heart failure (CHF) with reduced ejection fraction and wide QRS.
  • Limited data exist on CRT utilization and long-term outcomes in Japan.

Purpose of the Study:

  • To evaluate the appropriate use and outcomes of CRT in Japanese CHF patients.
  • To identify factors influencing CRT implantation and its impact on patient prognosis.

Main Methods:

  • Analysis of 3,447 symptomatic CHF patients from the CHART-2 Study.
  • Categorization into four groups based on CRT indication and implantation status.
  • Statistical adjustment for confounders to assess outcomes.

Main Results:

  • Only 47% of the 91 eligible patients received CRT.
  • Increasing age was significantly associated with not receiving CRT (OR 1.46 per 5-year increase).
  • Patients with an indication but no CRT (Group B) had the highest incidence of cardiovascular death and CHF admission.

Conclusions:

  • Suboptimal CRT utilization was observed in eligible Japanese CHF patients.
  • Aging is a significant barrier to CRT use.
  • Withholding CRT from indicated patients increases risks of mortality and hospitalization.

Keywords:
Cardiac resynchronization therapyHeart failurePrognosis

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