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Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
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Early Experience Using Proton Beam Therapy for Extremity Soft Tissue Sarcoma: A Multicenter Study.

Brady S Laughlin1, Michael A Golafshar1, Safia Ahmed2

  • 1Department of Radiation Oncology, Mayo Clinic, Phoenix, AZ, USA.

International Journal of Particle Therapy
|July 1, 2022
PubMed
Summary
This summary is machine-generated.

Proton beam therapy (PBT) shows excellent 1-year locoregional control for extremity soft tissue sarcoma (eSTS). This advanced radiation technique demonstrated a wound complication rate comparable to historical data in selected patients.

Keywords:
acute wound complicationextremity soft tissue sarcomaprotons

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Area of Science:

  • Oncology
  • Radiation Oncology
  • Surgical Oncology

Background:

  • Extremity soft tissue sarcomas (eSTS) present unique challenges for treatment planning.
  • Proton beam therapy (PBT) offers potential advantages for complex cases due to its precise dose delivery.
  • Evaluating early outcomes of PBT in eSTS is crucial for refining treatment strategies.

Purpose of the Study:

  • To analyze the early experience, toxicity, and outcomes of proton beam therapy (PBT) in patients with extremity soft tissue sarcoma (eSTS).
  • To assess the efficacy of PBT in managing large and anatomically challenging eSTS cases.
  • To compare PBT outcomes with historical controls regarding local control and wound complications.

Main Methods:

  • A retrospective study of 20 consecutive eSTS patients treated with pencil beam scanning PBT between June 2016 and October 2020.
  • Data collection included diagnostic, treatment, and toxicity characteristics from baseline to follow-up.
  • Wound complications were defined and analyzed, with statistical analysis performed using R software.

Main Results:

  • The 1-year locoregional control rate was 100% in the 20 studied eSTS patients.
  • Acute dermatitis toxicity was observed, with grade 2 in 40% and grade 3 in 15% of patients.
  • Acute wound complications occurred in 35% of patients, significantly associated with larger tumor size (median 16 cm vs. 6.3 cm).

Conclusions:

  • Proton beam therapy (PBT) demonstrates excellent local control for well-selected eSTS cases.
  • The acute wound complication rate appears comparable to historic controls.
  • Further long-term follow-up and dosimetric analyses are needed to fully elucidate the advantages of PBT in eSTS.