Related Experiment Video
Updated: Sep 6, 2025
Knee Arthrocentesis in Adults
Published on: February 25, 2022
Tranexamic acid in total knee replacement and total hip replacement - a single-center retrospective, observational
Wojciech Konarski1, Tomasz Poboży1, Martyna Hordowicz2
1Department of Orthopaedic Surgery, Ciechanów Hospital, Ciechanów.
Background:
Numerous strategies are used to decrease the risk of the need for [allogeneic blood transfusion (ABT)], including [tranexamic acid (TXA)].
Objective:
In a single-center retrospective observational study, we have assessed the impact of TXA on the need and average volume of blood used during transfusion.
Methods:
We have reviewed medical records of a total of 491 patients undergoing arthroplasty in our hospital from Dec 2016 to Dec 2019.
Results:
226 patients were administered TXA IV, and 265 did not receive an additional intervention. In the TXA group, 7/226 patients required ABT vs. 41/265 in the non-TXA group (p<0,001). The Non-TXA group required a significantly higher blood transfusion volume than the TXA group (mean 82,42 mL vs. 12,74 mL; p<0,001).
Conclusion:
We conclude that two doses of 1g TXA administered [intravenously (IV)] before incision and during skin suturing reduce the need for blood transfusion in patients undergoing JRS.
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