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Related Experiment Video

Updated: Sep 6, 2025

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

Published on: June 2, 2014

Early Onset Diffusion Abnormalities in Refractory Headache Disorders.

Jonathan D Santoro^1,2, Peter K Moon³, Michelle Han⁴

¹Division of Neurology, Department of Pediatrics, Children's Hospital Los Angeles, Los Angeles, CA, United States.

Frontiers in Neurology

|July 1, 2022

Summary

This summary is machine-generated.

Medically refractory migraine headache is associated with decreased apparent diffusion coefficient (ADC) values in multiple brain regions, suggesting early structural connectivity issues. These diffusion abnormalities in the brain may predict migraine severity.

Keywords:

MRI biomarker chronic pain diffusion imaging migraine

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Last Updated: Sep 6, 2025

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Published on: June 2, 2014

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Advanced Diffusion Imaging in The Hippocampus of Rats with Mild Traumatic Brain Injury

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Published on: August 14, 2019

Area of Science:

Neuroimaging
Neurology
Radiology

Background:

Limited neuroimaging biomarkers exist for headache medicine.
Early prediction of refractory headache disorders can guide timely treatment.

Purpose of the Study:

To investigate neuroimaging differences in brain volume and diffusion between individuals with medically refractory migraine headache and neurotypical controls.
To identify potential early biomarkers for predicting migraine refractoriness.

Main Methods:

Retrospective case-control study comparing 79 patients with medically refractory migraine headache to 74 neurotypical controls.
Analysis of MRI scans for volumetric and apparent diffusion coefficient (ADC) values in multiple brain regions.
Comparison of ADC values between patient and control groups.

Main Results:

Statistically significant differences in median ADC values were found in multiple brain subregions between groups (p < 0.001).
Individuals with medically refractory migraine headache showed significantly decreased median ADC values in the thalamus, caudate, putamen, pallidum, amygdala, brainstem, and cerebral white matter.
No volumetric differences were observed between the groups.

Conclusions:

Apparent diffusion coefficient (ADC) changes are measurable in multiple brain structures in individuals with medically refractory migraine headache.
These early ADC changes may indicate underlying structural connectivity issues that predispose individuals to refractory pain disorders.
Neuroimaging, specifically ADC mapping, may offer potential biomarkers for early identification of migraine refractoriness.