Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Applicability of European Society of Cardiology guidelines according to gross national income.

European heart journal·2022
Same author

Pragmatic randomized trials in drug development pose new ethical questions: a systematic review.

Drug discovery today·2015
Same author

Polysaccharide conjugate vaccine against pneumococcal pneumonia in adults.

The New England journal of medicine·2015
Same author

Common carotid intima-media thickness relates to cardiovascular events in adults aged <45 years.

Hypertension (Dallas, Tex. : 1979)·2015
Same author

A novel approach for establishing cardiovascular drug efficacy.

Nature reviews. Drug discovery·2014
Same author

Cardiovascular manifestations of HIV infection in children.

European journal of preventive cardiology·2014

Related Experiment Video

Updated: Sep 6, 2025

Working with Human Tissues for Translational Cancer Research
07:48

Working with Human Tissues for Translational Cancer Research

Published on: November 26, 2015

10.0K

When is it impractical to ask informed consent? A systematic review.

Sara Jm Laurijssen1, Rieke van der Graaf2, Wouter B van Dijk2

  • 1Department of Medical Ethics and Health Law, Leiden University Medical Center, Leiden University, Leiden, The Netherlands.

Clinical Trials (London, England)
|July 1, 2022
PubMed
Summary
This summary is machine-generated.

Clarifying when informed consent is impractical in research is crucial. This study defines "impractical" in research ethics, identifying conditions like participant harm or untraceable subjects as valid reasons for waivers.

Keywords:
Impracticableimpossibleinfeasibleinformed consentmodificationwaiver

More Related Videos

A Novel Method for Involving Women of Color at High Risk for Preterm Birth in Research Priority Setting
14:43

A Novel Method for Involving Women of Color at High Risk for Preterm Birth in Research Priority Setting

Published on: January 12, 2018

12.0K
A Familiarization Protocol Facilitates the Participation of Children with ASD in Electrophysiological Research
08:42

A Familiarization Protocol Facilitates the Participation of Children with ASD in Electrophysiological Research

Published on: July 31, 2017

8.3K

Related Experiment Videos

Last Updated: Sep 6, 2025

Working with Human Tissues for Translational Cancer Research
07:48

Working with Human Tissues for Translational Cancer Research

Published on: November 26, 2015

10.0K
A Novel Method for Involving Women of Color at High Risk for Preterm Birth in Research Priority Setting
14:43

A Novel Method for Involving Women of Color at High Risk for Preterm Birth in Research Priority Setting

Published on: January 12, 2018

12.0K
A Familiarization Protocol Facilitates the Participation of Children with ASD in Electrophysiological Research
08:42

A Familiarization Protocol Facilitates the Participation of Children with ASD in Electrophysiological Research

Published on: July 31, 2017

8.3K

Area of Science:

  • Biomedical Ethics
  • Research Methodology

Background:

  • Informed consent is fundamental in human subjects research.
  • Waivers of informed consent may be granted if research is socially valuable, low-risk, and consent is impractical.
  • The interpretation of 'impractical' in research ethics remains unclear.

Purpose of the Study:

  • To systematically review the interpretation of 'impractical' in the context of informed consent for biomedical research.
  • To clarify the conditions under which obtaining informed consent is considered impractical.

Main Methods:

  • Systematic review of international research ethics guidelines.
  • Identification of synonyms for 'impractical' based on ethical guidelines.
  • Literature search using PubMed, Embase, and Web of Science for articles on informed consent and impracticality.

Main Results:

  • Few international guidelines define 'impractical'.
  • A systematic review of 42 articles revealed four interpretations of impracticality: researcher burden, invalid study outcomes, participant harm, and participant meaninglessness.
  • Obtaining consent can be impractical due to untraceable participants or potential harm.

Conclusions:

  • While some conditions make consent impractical (e.g., untraceable participants, harm), researchers must strive to obtain consent.
  • Research invalidity due to consent issues should limit social value, not be deemed impractical.
  • Further research is needed to determine when waivers of informed consent based on impracticality are reasonable.