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Biosafety evaluation of dual-responsive neutrobots
Hongyue Zhang1,2, Liting Wang1, Zesheng Li1
1State Key Laboratory of Robotics and System, Harbin Institute of Technology, Harbin, 150001, China. zhiguangwu@hit.edu.cn.
Journal of Materials Chemistry. B
|July 1, 2022
Summary
Paclitaxel-loaded magnetic neutrophil-hybrid microrobots show minimal toxicity in mice. This finding supports the potential of these "neutrobots" for future biomedical applications.
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Pharmacology
Background:
- Paclitaxel (PTX) is a potent chemotherapy drug with a narrow therapeutic index.
- Developing targeted drug delivery systems is crucial to minimize systemic toxicity.
- Microrobots offer a novel platform for precise drug delivery.
Purpose of the Study:
- To evaluate the in vivo toxicity of paclitaxel-loaded magnetic neutrophil-hybrid swimming microrobots (neutrobots).
- To assess the safety profile of neutrobots after intravenous administration in a murine model.
Main Methods:
- Intravenous administration of PTX-loaded neutrobots to mice.
- Assessment of immunotoxicity, liver toxicity, and kidney toxicity at 72 hours post-administration.
- Dose: 3 × 10^6 PTX-loaded neutrobots.
Main Results:
- Mice exhibited minimal immunotoxicity after 72 hours.
- Minimal liver and kidney toxicity were observed at the tested dose.
- The drug-loaded neutrobots demonstrated a favorable safety profile.
Conclusions:
- PTX-loaded neutrobots show low in vivo toxicity in mice.
- The observed minimal toxicity suggests significant promise for neutrobots in biomedical applications.
- Neutrobots represent a potentially safe and effective drug delivery platform.
