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Updated: Sep 6, 2025

Chemoselective Modification of Viral Surfaces via Bioorthogonal Click Chemistry
Published on: August 19, 2012
Copper-Mediated Three-Component Reaction for the Synthesis of N-Acylsulfonamide on DNA
Solji Eom1,2, Taeyeon Kwon3,2, Da Yeon Lee3,2
1Graduate School of New Drug Discovery and Development, Chungnam National University, Daejeon 34134, Korea.
Abstract:
The DNA-encoded library (DEL) technology is a new method for discovering hit compounds for target proteins in the pharmaceutical industry. The N-acylsulfonamide functional group has been reported to exhibit various pharmacological activities, and based on this, the demand for a method that allows its introduction into the DEL platform has increased. In this report, a procedure for synthesizing N-acylsulfonamide functional groups applicable to DEL construction was developed in the presence of a copper reagent and water as a nucleophile from simple alkynes or sulfonyl azides, which are widely commercially available. Furthermore, we prove that a new alternative procedure can be used to construct a DNA-encoded library.
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