Related Experiment Video
Updated: Sep 6, 2025
05:27
An Intestinal Gut Organ Culture System for Analyzing Host-Microbiota Interactions
Published on: June 30, 2021
4.5K
The triple interactions between gut microbiota, mycobiota and host immunity
Jingpeng Yang1, Hong Yang2, Yanan Li1
1School of Food Science and Pharmaceutical Engineering, Nanjing Normal University, Nanjing, China.
Critical Reviews in Food Science and Nutrition
|July 1, 2022
Summary
The gut microbiome, comprising bacteria and fungi, influences immunity and disease. Understanding these interactions can guide effective microbiome-based therapies for inflammation and cancer immunotherapy.
Area of Science:
- Microbiology
- Immunology
- Gastroenterology
Background:
- The gut microbiome, consisting of microbiota and mycobiota, is crucial for immune development, metabolic regulation, and intestinal homeostasis.
- Interactions between gut bacteria, fungi, and host immunity are increasingly recognized for their role in infectious, immunodeficiency, and tumor-related diseases.
- Complex collaborative and antagonistic relationships exist between gut bacteria and fungi, impacting host health.
Purpose of the Study:
- To explore the significance of host-microbe interactions in disease pathogenesis and therapeutic outcomes.
- To review current interventions for modulating the gut microbiome, including probiotics, prebiotics, and fecal microbiota transplantation (FMT).
- To highlight the potential of specific next-generation probiotics like *Akkermansia muciniphila* and *Faecalibacterium prausnitzii* in inflammation and cancer immunotherapy.
Main Methods:
- Review of existing literature on gut microbiome composition and function.
- Analysis of the impact of bacterial-fungal-host interactions on disease.
- Evaluation of current and emerging therapeutic interventions targeting the gut microbiome.
Main Results:
- Gut bacteria and fungi play pivotal roles in host immunity and metabolic regulation.
- Interactions between gut microbes and host immunity directly influence disease progression and treatment efficacy.
- Certain probiotics, particularly *Akkermansia muciniphila* and *Faecalibacterium prausnitzii*, show promise in inflammation remission and cancer immunotherapy.
Conclusions:
- Modulating gut microbial communities through interventions like probiotics and FMT can impact host health.
- Further research into the mechanisms of microbial interactions is essential for developing precise and effective therapeutic strategies.
- Optimizing gut microbiome and immune modulation holds potential for improving anti-inflammatory and anti-cancer treatments.
Related Concept Videos
01:23Anatomy of the Intestines
73.6K
Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
73.6K
01:26Factors Affecting the Risk of Infection
12.2K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
12.2K
01:26Defense Mechanism Against Infection
7.2K
Natural flora, body system defenses, and inflammation are natural barriers of the body against infectious agents regardless of previous exposure. Normal floras of the human body refer to the microbial population that colonizes the skin and mucous membranes.
In addition, many body organ systems have unique defenses against infection. The skin is an intact, multilayered surface preventing invasion by microorganisms unless impaired. Mucous membranes lining the mouth, nose, and eyelids are barriers...
In addition, many body organ systems have unique defenses against infection. The skin is an intact, multilayered surface preventing invasion by microorganisms unless impaired. Mucous membranes lining the mouth, nose, and eyelids are barriers...
7.2K
01:29Microorganisms in Medicine and Therapeutics
305
Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
305
01:05Physiology of Enteric Nervous System and Gut Health
408
The gastrointestinal tract, responsible for the digestion and absorption of nutrients, is safeguarded by the intestinal barrier, which consists of secretory, physical, and immune components. At the forefront is the secretory barrier, composed of essential elements such as mucus, gut microbiota, and defense proteins. They collaborate to break down food particles, facilitate nutrient absorption, and maintain optimal gut health. These secretory components ensure the smooth functioning of the...
408
01:50What is Monogastric Digestion?
72.3K
The human body contains a monogastric digestive system. In a monogastric digestive system, the stomach only contains one chamber in which it digests food. Several other animal species also have monogastric digestive systems, including pigs, horses, dogs, and birds. This chapter, however, focuses on the human digestive system.
72.3K